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@ARTICLE{Chen:131719,
      author       = {C. Chen$^*$ and C. Stock$^*$ and M. Hoffmeister$^*$ and H.
                      Brenner$^*$},
      title        = {{P}ublic health impact of colonoscopy use on colorectal
                      cancer mortality in {G}ermany and the {U}nited {S}tates.},
      journal      = {Gastrointestinal endoscopy},
      volume       = {87},
      number       = {1},
      issn         = {0016-5107},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-00025},
      pages        = {213 - 221.e2},
      year         = {2018},
      abstract     = {Colonoscopy has been demonstrated to be effective in
                      reducing colorectal cancer (CRC) incidence and mortality and
                      has been widely used for primary CRC screening in Germany
                      and the United States. We performed a population-based
                      analysis to evaluate and compare the public health impact of
                      recent colonoscopy use on CRC deaths among adults aged 55 to
                      79 years in Germany and the United States from 2008
                      to 2011.The epidemiologic metrics of attributable fraction
                      and prevented fraction as well as the impact numbers were
                      calculated using colonoscopy utilization data from
                      nationally representative health surveys, relative risk
                      estimates from medical literature, and CRC death registry
                      data.Overall, $36.6\%$ $(95\%$ credible interval [CrI],
                      $27.3\%-45.5\%)$ of CRC deaths in Germany were estimated to
                      be attributable to nonuse of colonoscopy, compared with the
                      U.S. estimates of $38.2\%$ $(95\%$ CrI, $28.6\%-47.1\%)$ and
                      $33.6\%$ $(95\%$ CrI, $24.8\%-42.2\%)$ for years 2008 to
                      2009 and 2010 to 2011, respectively. The proportion of CRC
                      deaths theoretically prevented by colonoscopy use within 10
                      years was $30.7\%$ $(95\%$ CrI, $24.8\%-35.7\%)$ in Germany,
                      whereas in the United States this proportion ranged from
                      $29.0\%$ $(95\%$ CrI, $23.4\%-33.6\%)$ for 2008 to 2009 to
                      $33.9\%$ $(95\%$ CrI, $27.4\%-39.2\%)$ for 2010
                      to 2011.Recent colonoscopy use is likely to have prevented
                      a considerable fraction of CRC mortality in both countries,
                      and more deaths could be avoided by increasing colonoscopy
                      use in the target population. Attributable and prevented
                      fraction can provide valuable information on the public
                      health impact of colonoscopy use and guide policymaking.},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28431951},
      doi          = {10.1016/j.gie.2017.04.005},
      url          = {https://inrepo02.dkfz.de/record/131719},
}