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@ARTICLE{Feng:131720,
      author       = {W. Feng$^*$ and H.-K. Liu$^*$ and D. Kawauchi$^*$},
      title        = {{CRISPR}-engineered genome editing for the next generation
                      neurological disease modeling.},
      journal      = {Progress in neuro-psychopharmacology $\&$ biological
                      psychiatry},
      volume       = {81},
      issn         = {0278-5846},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-00026},
      pages        = {459 - 467},
      year         = {2018},
      note         = {DKFZ-ZMBH-Allianz},
      abstract     = {Neurological disorders often occur because of failure of
                      proper brain development and/or appropriate maintenance of
                      neuronal circuits. In order to understand roles of causative
                      factors (e.g. genes, cell types) in disease development,
                      generation of solid animal models has been one of
                      straight-forward approaches. Recent next generation
                      sequencing studies on human patient-derived clinical samples
                      have identified various types of recurrent mutations in
                      individual neurological diseases. While these discoveries
                      have prompted us to evaluate impact of mutated genes on
                      these neurological diseases, a feasible but flexible genome
                      editing tool had remained to be developed. An advance of
                      genome editing technology using the clustered regularly
                      interspaced short palindromic repeats (CRISPR) with the
                      CRISPR-associated protein (Cas) offers us a tremendous
                      potential to create a variety of mutations in the cell,
                      leading to 'next generation' disease models carrying
                      disease-associated mutations. We will here review recent
                      progress of CRISPR-based brain disease modeling studies and
                      discuss future requirement to tackle current difficulties in
                      usage of these technologies.},
      subtyp        = {Review Article},
      cin          = {A240 / B062},
      ddc          = {610},
      cid          = {I:(DE-He78)A240-20160331 / I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28536069},
      doi          = {10.1016/j.pnpbp.2017.05.019},
      url          = {https://inrepo02.dkfz.de/record/131720},
}