TY  - JOUR
AU  - Jansen, Henning
AU  - Jänsch, Andrea
AU  - Breitling, Lutz
AU  - Hoppe, Liesa
AU  - Dallmeier, Dhayana
AU  - Schmucker, Roman
AU  - Brenner, Hermann
AU  - Koenig, Wolfgang
AU  - Rothenbacher, Dietrich
TI  - Hs-cTroponins for the prediction of recurrent cardiovascular events in patients with established CHD - A comparative analysis from the KAROLA study.
JO  - International journal of cardiology
VL  - 250
SN  - 0167-5273
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2018-00029
SP  - 247 - 252
PY  - 2018
AB  - High-sensitivity Troponins (hs-cTnT and hs-cTnI) are established biomarkers to identify patients with an acute myocardial infarction. However, data comparing the capacity of these two subtypes in predicting recurrent cardiovascular disease (CVD) events in a population with stable coronary heart disease (CHD) after adjustment for several other modern biomarkers are lacking.We measured both troponins at baseline in 1068 CHD patients, followed them for 13years, assessed a combined CVD endpoint, and adjusted for multiple traditional and novel risk factors.Both troponins correlated significantly with age, low and high BMI, male gender, statin therapy, and emerging biomarkers (e.g. cystatin C, NT-proBNP, GDF-15, hsCRP or galectin 3). During follow-up of 13years, 267 fatal and non-fatal CVD events occurred. Top quartiles of both troponin concentrations were significantly associated with CVD events compared to the bottom quartile after adjustment for age, gender and established CVD risk factors (hs-cTnT: hazard ratio (HR) 2.54 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:29169757
DO  - DOI:10.1016/j.ijcard.2017.08.062
UR  - https://inrepo02.dkfz.de/record/131723
ER  -