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@ARTICLE{Jansen:131723,
      author       = {H. Jansen and A. Jänsch and L. Breitling$^*$ and L.
                      Hoppe$^*$ and D. Dallmeier and R. Schmucker and H.
                      Brenner$^*$ and W. Koenig and D. Rothenbacher},
      title        = {{H}s-c{T}roponins for the prediction of recurrent
                      cardiovascular events in patients with established {CHD} -
                      {A} comparative analysis from the {KAROLA} study.},
      journal      = {International journal of cardiology},
      volume       = {250},
      issn         = {0167-5273},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-00029},
      pages        = {247 - 252},
      year         = {2018},
      abstract     = {High-sensitivity Troponins (hs-cTnT and hs-cTnI) are
                      established biomarkers to identify patients with an acute
                      myocardial infarction. However, data comparing the capacity
                      of these two subtypes in predicting recurrent cardiovascular
                      disease (CVD) events in a population with stable coronary
                      heart disease (CHD) after adjustment for several other
                      modern biomarkers are lacking.We measured both troponins at
                      baseline in 1068 CHD patients, followed them for 13years,
                      assessed a combined CVD endpoint, and adjusted for multiple
                      traditional and novel risk factors.Both troponins correlated
                      significantly with age, low and high BMI, male gender,
                      statin therapy, and emerging biomarkers (e.g. cystatin C,
                      NT-proBNP, GDF-15, hsCRP or galectin 3). During follow-up of
                      13years, 267 fatal and non-fatal CVD events occurred. Top
                      quartiles of both troponin concentrations were significantly
                      associated with CVD events compared to the bottom quartile
                      after adjustment for age, gender and established CVD risk
                      factors (hs-cTnT: hazard ratio (HR) 2.54 $(95\%$ CI,
                      1.60-4.03), p for trend: <0.0001; hs-cTnI: HR 2.20 $(95\%$
                      CI, 1.44-3.36), p for trend: <0.0002 and 0.0003). However,
                      after adjustment for other emerging biomarkers, the
                      associations were no longer statistically significant
                      (hs-cTnT: HR 1.63 $(95\%$ CI, 0.97-2.73), p for trend: 0.17;
                      hs-cTnI: HR 1.61 $(95\%$ CI, 1.00-2.60), p for trend:
                      0.067).Both troponins are reliable biomarkers of recurrent
                      cardiovascular events, especially if other novel, important
                      markers such as NT-proBNP, GDF-15 and galectin 3 are not
                      available. Nevertheless, a further workup is still needed to
                      explain the complex interaction of biomarkers indicating
                      vascular and myocardial function.},
      cin          = {C070 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29169757},
      doi          = {10.1016/j.ijcard.2017.08.062},
      url          = {https://inrepo02.dkfz.de/record/131723},
}