000131730 001__ 131730
000131730 005__ 20240229105009.0
000131730 0247_ $$2doi$$a10.1016/j.ydbio.2017.11.007
000131730 0247_ $$2pmid$$apmid:29155043
000131730 0247_ $$2ISSN$$a0012-1606
000131730 0247_ $$2ISSN$$a1095-564X
000131730 037__ $$aDKFZ-2018-00036
000131730 041__ $$aeng
000131730 082__ $$a570
000131730 1001_ $$0P:(DE-He78)391d81459dde44e1e2f63d940ce91a23$$aMartins, Leila$$b0$$eFirst author
000131730 245__ $$aStk33 is required for spermatid differentiation and male fertility in mice.
000131730 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2018
000131730 3367_ $$2DRIVER$$aarticle
000131730 3367_ $$2DataCite$$aOutput Types/Journal article
000131730 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1660042440_23717
000131730 3367_ $$2BibTeX$$aARTICLE
000131730 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000131730 3367_ $$00$$2EndNote$$aJournal Article
000131730 520__ $$aSpermiogenesis is the final phase during sperm cell development in which round spermatids undergo dramatic morphological changes to generate spermatozoa. Here we report that the serine/threonine kinase Stk33 is essential for the differentiation of round spermatids into functional sperm cells and male fertility. Constitutive Stk33 deletion in mice results in severely malformed and immotile spermatozoa that are particularly characterized by disordered structural tail elements. Stk33 expression first appears in primary spermatocytes, and targeted deletion of Stk33 in these cells recapitulates the defects observed in constitutive knockout mice, confirming a germ cell-intrinsic function. Stk33 protein resides in the cytoplasm and partially co-localizes with the caudal end of the manchette, a transient structure that guides tail elongation, in elongating spermatids, and loss of Stk33 leads to the appearance of a tight, straight and elongated manchette. Together, these results identify Stk33 as an essential regulator of spermatid differentiation and male fertility.
000131730 536__ $$0G:(DE-HGF)POF3-317$$a317 - Translational cancer research (POF3-317)$$cPOF3-317$$fPOF III$$x0
000131730 588__ $$aDataset connected to CrossRef, PubMed,
000131730 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProtein-Serine-Threonine Kinases
000131730 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aStk33 protein, mouse
000131730 7001_ $$0P:(DE-He78)a410a79b9219ac5ab93ddb1f58567583$$aBung, Raffaela$$b1$$eFirst author
000131730 7001_ $$0P:(DE-He78)05ca696396b7d413c64230d84aa8302b$$aKoch, Stefan$$b2
000131730 7001_ $$0P:(DE-He78)027fe772631b4a2d7a45c439cdd75ff2$$aRichter, Karsten$$b3
000131730 7001_ $$0P:(DE-He78)aa78aaf55cae10e962af59a882e11a50$$aSchwarzmüller, Laura$$b4
000131730 7001_ $$0P:(DE-He78)991812504757f41fde96045ecacfe0f5$$aTerhardt, Dorothee$$b5
000131730 7001_ $$0P:(DE-He78)577ee6d3243f8d724c54855ef8df84a8$$aKurtulmus, Bahtiyar$$b6
000131730 7001_ $$0P:(DE-He78)483ad6be7d7fe19e48db9cce86efd70e$$aNiehrs, Christof$$b7
000131730 7001_ $$aRouhi, Arefeh$$b8
000131730 7001_ $$aLohmann, Ingrid$$b9
000131730 7001_ $$0P:(DE-He78)5138c10dcd0901d001d67a31423402b5$$aPereira, Gislene$$b10
000131730 7001_ $$0P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aFröhling, Stefan$$b11
000131730 7001_ $$0P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aGlimm, Hanno$$b12
000131730 7001_ $$0P:(DE-He78)2c1a21d1cf5fdc9e297512c9d1354250$$aScholl, Claudia$$b13$$eLast author
000131730 773__ $$0PERI:(DE-600)1463203-2$$a10.1016/j.ydbio.2017.11.007$$gVol. 433, no. 1, p. 84 - 93$$n1$$p84 - 93$$tDevelopmental biology$$v433$$x0012-1606$$y2018
000131730 909CO $$ooai:inrepo02.dkfz.de:131730$$pVDB
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)391d81459dde44e1e2f63d940ce91a23$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a410a79b9219ac5ab93ddb1f58567583$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000131730 9101_ $$0I:(DE-HGF)0$$6P:(DE-He78)05ca696396b7d413c64230d84aa8302b$$aExternal Institute$$b2$$kExtern
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)027fe772631b4a2d7a45c439cdd75ff2$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)aa78aaf55cae10e962af59a882e11a50$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)991812504757f41fde96045ecacfe0f5$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)577ee6d3243f8d724c54855ef8df84a8$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)483ad6be7d7fe19e48db9cce86efd70e$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5138c10dcd0901d001d67a31423402b5$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000131730 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)2c1a21d1cf5fdc9e297512c9d1354250$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000131730 9131_ $$0G:(DE-HGF)POF3-317$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTranslational cancer research$$x0
000131730 9141_ $$y2018
000131730 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000131730 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bDEV BIOL : 2015
000131730 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000131730 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000131730 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000131730 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000131730 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000131730 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000131730 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000131730 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000131730 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000131730 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000131730 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000131730 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000131730 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000131730 9201_ $$0I:(DE-He78)G102-20160331$$kG102$$lAngewandte Funktionelle Genomik$$x0
000131730 9201_ $$0I:(DE-He78)A050-20160331$$kA050$$lA050 Molekulare Embryologie$$x1
000131730 9201_ $$0I:(DE-He78)W230-20160331$$kW230$$lElektronenmikroskopie$$x2
000131730 9201_ $$0I:(DE-He78)A180-20160331$$kA180$$lA180 Molecular Biology of Centrosomes$$x3
000131730 9201_ $$0I:(DE-He78)G100-20160331$$kG100$$lTranslationale Onkologie$$x4
000131730 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x5
000131730 980__ $$ajournal
000131730 980__ $$aVDB
000131730 980__ $$aI:(DE-He78)G102-20160331
000131730 980__ $$aI:(DE-He78)A050-20160331
000131730 980__ $$aI:(DE-He78)W230-20160331
000131730 980__ $$aI:(DE-He78)A180-20160331
000131730 980__ $$aI:(DE-He78)G100-20160331
000131730 980__ $$aI:(DE-He78)L101-20160331
000131730 980__ $$aUNRESTRICTED