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@ARTICLE{Martins:131730,
      author       = {L. Martins$^*$ and R. Bung$^*$ and S. Koch and K.
                      Richter$^*$ and L. Schwarzmüller$^*$ and D. Terhardt$^*$
                      and B. Kurtulmus$^*$ and C. Niehrs$^*$ and A. Rouhi and I.
                      Lohmann and G. Pereira$^*$ and S. Fröhling$^*$ and H.
                      Glimm$^*$ and C. Scholl$^*$},
      title        = {{S}tk33 is required for spermatid differentiation and male
                      fertility in mice.},
      journal      = {Developmental biology},
      volume       = {433},
      number       = {1},
      issn         = {0012-1606},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-00036},
      pages        = {84 - 93},
      year         = {2018},
      abstract     = {Spermiogenesis is the final phase during sperm cell
                      development in which round spermatids undergo dramatic
                      morphological changes to generate spermatozoa. Here we
                      report that the serine/threonine kinase Stk33 is essential
                      for the differentiation of round spermatids into functional
                      sperm cells and male fertility. Constitutive Stk33 deletion
                      in mice results in severely malformed and immotile
                      spermatozoa that are particularly characterized by
                      disordered structural tail elements. Stk33 expression first
                      appears in primary spermatocytes, and targeted deletion of
                      Stk33 in these cells recapitulates the defects observed in
                      constitutive knockout mice, confirming a germ cell-intrinsic
                      function. Stk33 protein resides in the cytoplasm and
                      partially co-localizes with the caudal end of the manchette,
                      a transient structure that guides tail elongation, in
                      elongating spermatids, and loss of Stk33 leads to the
                      appearance of a tight, straight and elongated manchette.
                      Together, these results identify Stk33 as an essential
                      regulator of spermatid differentiation and male fertility.},
      keywords     = {Protein-Serine-Threonine Kinases (NLM Chemicals) / Stk33
                      protein, mouse (NLM Chemicals)},
      cin          = {G102 / A050 / W230 / A180 / G100 / L101},
      ddc          = {570},
      cid          = {I:(DE-He78)G102-20160331 / I:(DE-He78)A050-20160331 /
                      I:(DE-He78)W230-20160331 / I:(DE-He78)A180-20160331 /
                      I:(DE-He78)G100-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29155043},
      doi          = {10.1016/j.ydbio.2017.11.007},
      url          = {https://inrepo02.dkfz.de/record/131730},
}