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@ARTICLE{Twardella:131739,
author = {D. Twardella and K. Geiss and M. Radespiel-Tröger and A.
Benner$^*$ and J. H. Ficker and M. Meyer},
title = {[{T}rends in incidence of lung cancer according to
histological subtype among men and women in {G}ermany :
{A}nalysis of cancer registry data with the application of
multiple imputation techniques].},
journal = {Bundesgesundheitsblatt, Gesundheitsforschung,
Gesundheitsschutz},
volume = {61},
number = {1},
issn = {1437-1588},
address = {Berlin},
publisher = {Springer},
reportid = {DKFZ-2018-00045},
pages = {20 - 31},
year = {2018},
abstract = {Lung cancer can be described by histological subtype, of
which small cell, squamous cell and adenocarcinoma are the
most common. International data show that adenocarcinoma is
becoming the dominant histological subtype of lung cancer
although the relative risk due to smoking has been found to
be smaller than that for other histological subtypes.The aim
of the analysis was to describe the time trends in incidence
of lung cancer among women and men in Germany according to
histological subtype.All lung cancer cases (ICD-10 C33-C34)
newly diagnosed between 2003 and 2012 and collected by the
epidemiologic cancer registries of the German federal states
with average completeness of registration of at least $90\%$
were considered and grouped into histologic subtypes. If
data on tumor histology were not microscopically verified or
unspecific, multiple imputation techniques were applied to
estimate the histologic subtype.Among women age-standardized
lung cancer rates increased considerably between 2003 and
2012 (annual percent change APC = $2.7\%),$ mostly driven
by a rising adenocarcinoma incidence (APC = $4.7\%).$
Among men overall lung cancer rates decreased during the
same time (APC = $-1.7\%).$ Still, a slight increase in
adenocarcinoma incidence was also observed in men (APC =
$1.0\%).The$ rising incidence of adenocarcinoma of the lung
is alarming. The cancer registry data do not allow risk
factor analysis. In the international discussion, the
introduction of filter cigarettes as well as the changing
composition of cigarettes has been hypothesized as being
responsible. Further epidemiologic studies are strongly
needed.},
cin = {C060},
ddc = {610},
cid = {I:(DE-He78)C060-20160331},
pnm = {313 - Cancer risk factors and prevention (POF3-313)},
pid = {G:(DE-HGF)POF3-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29181809},
doi = {10.1007/s00103-017-2659-x},
url = {https://inrepo02.dkfz.de/record/131739},
}