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@ARTICLE{Zuo:131744,
      author       = {H. Zuo and P. M. Ueland and Ø. Midttun and S. E. Vollset
                      and G. S. Tell and D. Theofylaktopoulou and R. C. Travis and
                      M.-C. Boutron-Ruault and A. Fournier and G. Severi and M.
                      Kvaskoff and H. Boeing and M. M. Bergmann and R.
                      Turzanski-Fortner$^*$ and R. Kaaks$^*$ and A. Trichopoulou
                      and A. Kotanidou and P. Lagiou and D. Palli and S. Sieri and
                      S. Panico and H. B. Bueno-de-Mesquita and P. H. Peeters and
                      K. Grankvist and M. Johansson and A. Agudo and J. R. Q.
                      Garcia and N. Larranaga and M.-J. Sanchez and M. D.
                      Chirlaque and E. Ardanaz and S.-C. Chuang and V. Gallo and
                      P. Brennan and M. Johansson and A. Ulvik},
      title        = {{R}esults from the {E}uropean {P}rospective {I}nvestigation
                      into {C}ancer and {N}utrition {L}ink {V}itamin {B}6
                      {C}atabolism and {L}ung {C}ancer {R}isk.},
      journal      = {Cancer research},
      volume       = {78},
      number       = {1},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2018-00050},
      pages        = {302 - 308},
      year         = {2018},
      abstract     = {Circulating pyridoxal-5'-phosphate (PLP) has been linked to
                      lung cancer risk. The PAr index, defined as the ratio
                      4-pyridoxic acid/(pyridoxal + PLP), reflects increased
                      vitamin B6 catabolism during inflammation. PAr has been
                      defined as a marker of lung cancer risk in a prospective
                      cohort study, but analysis of a larger numbers of cases are
                      needed to deepen the significance of this study. Here, we
                      conducted a nested case-control study within the European
                      Prospective Investigation into Cancer and Nutrition (EPIC, n
                      = 521,330), which included 892 incident lung cancer cases
                      and 1,748 controls matched by center, gender, date of blood
                      collection, and date of birth. The association of PAr with
                      risk of lung cancer was evaluated by using conditional
                      logistic regression. Study participants with elevated PAr
                      experienced higher risk of lung cancer in a dose-response
                      fashion, with a doubling in PAr levels associated with
                      $52\%$ higher odds of lung cancer after adjustment for
                      tobacco smoking, serum cotinine levels, educational
                      attainment, and BMI [OR, 1.52; $95\%$ confidence interval
                      (CI) 1.27-1.81; P < 0.001]. Additional adjustment for intake
                      of vegetables and fruits and physical activity did not
                      materially affect risk association. The association of PAr
                      with lung cancer risk was similar in both genders but
                      slightly stronger in former smokers and in participants
                      diagnosed with squamous cell carcinoma. This study provides
                      robust evidence that increased vitamin B6 catabolism is
                      independently associated with a higher risk of future lung
                      cancer.Significance: This large cohort study firmly
                      establishes an association between an index of vitamin B6
                      levels with lung cancer risk. Cancer Res; 78(1); 302-8.
                      ©2017 AACR.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29070616},
      doi          = {10.1158/0008-5472.CAN-17-1923},
      url          = {https://inrepo02.dkfz.de/record/131744},
}