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000131766 1001_ $$00000-0003-4661-0763$$aBarrdahl, Myrto$$b0$$eFirst author
000131766 245__ $$aA comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium.
000131766 260__ $$aBognor Regis$$bWiley-Liss$$c2018
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000131766 520__ $$aWe assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer cases from the Breast and Prostate Cancer Cohort Consortium (BPC3). Three SNPs showed at least one nominally significant association in homozygous minor versus homozygous major models. ACVR2A-rs2382112 (ORhom  = 3.05, 95%CI = 1.72-5.44, Phom  = 1.47 × 10-4 ), MAST2-rs12124649 (ORhom  = 1.73, 95% CI =1.18-2.54, Phom  = 5.24 × 10-3 ), and INSR-rs10500204 (ORhom  = 1.96, 95% CI = 1.44-2.67, Phom =1.68 × 10-5 ) were associated with increased risk of BCIS; however, only the latter association was significant after correcting for multiple testing. Furthermore, INSR-rs10500204 was more strongly associated with the risk of BCIS than invasive disease in case-only analyses using the homozygous minor versus homozygous major model (ORhom  = 1.78, 95% CI = 1.30-2.44, Phom  = 3.23 × 10-4 ). The SNP INSR-rs10500204 is located in an intron of the INSR gene and is likely to affect binding of the promyelocytic leukemia (PML) protein. The PML gene is known as a tumor suppressor and growth regulator in cancer. However, it is not clear on what pathway the A-allele of rs10500204 could operate to influence the binding of the protein. Hence, functional studies are warranted to investigate this further.
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000131766 7001_ $$00000-0002-4261-4583$$aCanzian, Federico$$b1
000131766 7001_ $$aGaudet, Mia M$$b2
000131766 7001_ $$aGapstur, Susan M$$b3
000131766 7001_ $$aTrichopoulou, Antonia$$b4
000131766 7001_ $$aTsilidis, Kostas$$b5
000131766 7001_ $$avan Gils, Carla H$$b6
000131766 7001_ $$00000-0001-7938-8893$$aBorgquist, Signe$$b7
000131766 7001_ $$aWeiderpass, Elisabete$$b8
000131766 7001_ $$aKhaw, Kay-Tee$$b9
000131766 7001_ $$aGiles, Graham G$$b10
000131766 7001_ $$aMilne, Roger L$$b11
000131766 7001_ $$aLe Marchand, Loic$$b12
000131766 7001_ $$aHaiman, Christopher$$b13
000131766 7001_ $$aLindström, Sara$$b14
000131766 7001_ $$aKraft, Peter$$b15
000131766 7001_ $$aHunter, David J$$b16
000131766 7001_ $$aZiegler, Regina$$b17
000131766 7001_ $$aChanock, Stephen J$$b18
000131766 7001_ $$aYang, Xiaohong R$$b19
000131766 7001_ $$aBuring, Julie E$$b20
000131766 7001_ $$aLee, I-Min$$b21
000131766 7001_ $$00000-0003-3751-3929$$aKaaks, Rudolf$$b22
000131766 7001_ $$00000-0003-3220-9944$$aCampa, Daniele$$b23
000131766 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.31145$$gVol. 142, no. 6, p. 1182 - 1188$$n6$$p1182 - 1188$$tInternational journal of cancer$$v142$$x0020-7136$$y2018
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