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@ARTICLE{Brandelik:131770,
      author       = {S. C. Brandelik and J. Krzykalla$^*$ and T. Hielscher$^*$
                      and J. Hillengass and J. K. Kloth and H. U. Kauczor and M.
                      A. Weber},
      title        = {[{F}ocal lesions in whole-body {MRI} in multiple myeloma :
                      {Q}uantification of tumor mass and correlation with
                      disease-related parameters and prognosis].},
      journal      = {Der Radiologe},
      volume       = {58},
      number       = {1},
      issn         = {1432-2102},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2018-00067},
      pages        = {72 - 78},
      year         = {2018},
      abstract     = {In this study, we evaluated methods of quantification of
                      tumor mass in whole-body MRI (wb-MRI) in multiple myeloma
                      and correlated these with disease-related parameters in
                      serum and bone marrow.We retrospectively evaluated wb-MRIs
                      of 52 patients with focal infiltration pattern and a total
                      of 700 focal lesions (subsequently called lesions). We
                      determined the longest diameter (LD), the segmented volume
                      (SV), and the morphology (spherical or non-spherical). We
                      correlated total number/volume of the lesions with clinical
                      parameters and prognosis and furthermore LD with SV. After
                      that we analyzed the agreement of SV and estimated volume
                      (EV) using the volume formula of a sphere based on
                      LD.Results showed no significant correlations of total
                      number/volume with prognosis or clinical parameters. The
                      latter were situated predominantly in the normal range.
                      Furthermore, $10\%$ of lesions were spherical. SV and LD
                      correlated significantly in single lesions and on patient
                      level. SV was in lesions <6 cm3 systematically larger and
                      in lesions ≥6 cm3 smaller than EV. In $95\%,$ we found
                      in small lesions a deviation of EV versus SV from
                      +0.9 cm3 to -4.6 cm3 and in large lesions from
                      +160 cm3 to -111 cm3 (EV-SV).Quantification of tumor
                      mass in the focal infiltration pattern is performed more
                      accurately by volumetry than LD due to the predominant
                      existence of non-spherical lesions. The patient cohort with
                      clinical parameters predominantly in the normal range is
                      distributed to ISS stage I and partly pretreated, a fact
                      that makes interpretation of absent correlations more
                      difficult. Consider also a variation in activitiy of lesions
                      and a diffuse infiltration not detectable by MRI.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28905085},
      doi          = {10.1007/s00117-017-0299-7},
      url          = {https://inrepo02.dkfz.de/record/131770},
}