guest ::
| Home > Publications database > CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN. > print |
| Home > Publications database > CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN. > print |
| 001 | 131785 | ||
| 005 | 20240229105013.0 | ||
| 024 | 7 | _ | |a 10.1007/s00018-017-2638-2 |2 doi |
| 024 | 7 | _ | |a pmid:28879433 |2 pmid |
| 024 | 7 | _ | |a 0014-4754 |2 ISSN |
| 024 | 7 | _ | |a 1420-682X |2 ISSN |
| 024 | 7 | _ | |a 1420-9071 |2 ISSN |
| 024 | 7 | _ | |a altmetric:27062562 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-00082 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Lafarga, Vanesa |b 0 |
| 245 | _ | _ | |a CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN. |
| 260 | _ | _ | |a Basel |c 2018 |b Birkhäuser |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521449916_14509 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a DKFZ-ZMBH-Allianz |
| 520 | _ | _ | |a The survival of motor neuron (SMN) protein plays an essential role in the biogenesis of spliceosomal snRNPs and the molecular assembly of Cajal bodies (CBs). Deletion of or mutations in the SMN1 gene cause spinal muscular atrophy (SMA) with degeneration and loss of motor neurons. Reduced SMN levels in SMA lead to deficient snRNP biogenesis with consequent splicing pathology. Here, we demonstrate that SMN is a novel and specific target of the acetyltransferase CBP (CREB-binding protein). Furthermore, we identify lysine (K) 119 as the main acetylation site in SMN. Importantly, SMN acetylation enhances its cytoplasmic localization, causes depletion of CBs, and reduces the accumulation of snRNPs in nuclear speckles. In contrast, the acetylation-deficient SMNK119R mutant promotes formation of CBs and a novel category of promyelocytic leukemia (PML) bodies enriched in this protein. Acetylation increases the half-life of SMN protein, reduces its cytoplasmic diffusion rate and modifies its interactome. Hence, SMN acetylation leads to its dysfunction, which explains the ineffectiveness of HDAC (histone deacetylases) inhibitors in SMA therapy despite their potential to increase SMN levels. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Tapia, Olga |0 0000-0002-0802-7975 |b 1 |
| 700 | 1 | _ | |a Sharma, Sahil |0 P:(DE-He78)0ccaac599df473c058110b44c7b292c0 |b 2 |u dkfz |
| 700 | 1 | _ | |a Bengoechea, Rocio |b 3 |
| 700 | 1 | _ | |a Stoecklin, Georg |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Lafarga, Miguel |b 5 |
| 700 | 1 | _ | |a Berciano, Maria T |b 6 |
| 773 | _ | _ | |a 10.1007/s00018-017-2638-2 |g Vol. 75, no. 3, p. 527 - 546 |0 PERI:(DE-600)1458497-9 |n 3 |p 527 - 546 |t Cellular and molecular life sciences |v 75 |y 2018 |x 1420-9071 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:131785 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)0ccaac599df473c058110b44c7b292c0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-HGF)0 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-311 |2 G:(DE-HGF)POF3-300 |v Signalling pathways, cell and tumor biology |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1120 |2 StatID |b BIOSIS Reviews Reports And Meetings |
| 920 | 1 | _ | |0 I:(DE-He78)A200-20160331 |k A200 |l Posttranskriptionelle Genregulation |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)A200-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|