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@ARTICLE{Schmidt:131805,
      author       = {M. E. Schmidt$^*$ and J. Wiskemann and A. Schneeweiss and
                      K. Potthoff and C. M. Ulrich and K. Steindorf$^*$},
      title        = {{D}eterminants of physical, affective, and cognitive
                      fatigue during breast cancer therapy and 12 months
                      follow-up.},
      journal      = {International journal of cancer},
      volume       = {142},
      number       = {6},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-00102},
      pages        = {1148 - 1157},
      year         = {2018},
      abstract     = {Fatigue is common in cancer survivors but often
                      insufficiently treated. Due to its complexity a
                      one-size-fits-all treatment seems not appropriate. To gain
                      more information on influencing factors and sub-dimensions
                      of fatigue we investigated potential determinants and
                      correlates of physical, affective, and cognitive fatigue in
                      breast cancer survivors during and after adjuvant therapy.
                      Within the follow-up of two randomized controlled trials
                      physical, affective, and cognitive fatigue were repeatedly
                      assessed during and up to 12 months after cancer therapy
                      with the 20-item Fatigue Assessment Questionnaire in 255
                      breast cancer survivors. Determinants of the different
                      fatigue dimensions over time were explored with linear mixed
                      models. Chemotherapy appeared as significant precipitating
                      factor for physical fatigue. However, type of cancer therapy
                      had no impact on fatigue one year post-treatment. Obesity
                      was significantly associated with increased physical fatigue
                      throughout all time points (Δ=15.5 at 12 months) whereas
                      exercise appeared to be beneficial (Δ = -6.3). In
                      contrast, affective fatigue was significantly associated
                      with poor social support and worries about the future. In
                      addition, poor sleep quality and previous use of
                      psychopharmaceuticals were significantly associated with
                      physical, affective, as well as cognitive fatigue. Further,
                      hot flashes were associated with increased physical and
                      cognitive fatigue. In conclusion, the broad diagnosis
                      fatigue in cancer survivors needs to be recognized as a
                      diversity of symptoms determined by specific characteristics
                      and likely different etiologies. Taking potential
                      influencing factors such as obesity, physical inactivity,
                      sleep problems, hot flashes, lack of social support, or
                      psychological disorders into consideration might enable a
                      better, individually-tailored fatigue treatment.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29082588},
      doi          = {10.1002/ijc.31138},
      url          = {https://inrepo02.dkfz.de/record/131805},
}