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@ARTICLE{Zimmer:131822,
      author       = {P. Zimmer$^*$ and S. Trebing and U. Timmers-Trebing and A.
                      Schenk and R. Paust and W. Bloch and R. Rudolph and F.
                      Streckmann and F. T. Baumann},
      title        = {{E}ight-week, multimodal exercise counteracts a progress of
                      chemotherapy-induced peripheral neuropathy and improves
                      balance and strength in metastasized colorectal cancer
                      patients: a randomized controlled trial.},
      journal      = {Supportive care in cancer},
      volume       = {26},
      number       = {2},
      issn         = {1433-7339},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2018-00117},
      pages        = {615 - 624},
      year         = {2018},
      abstract     = {Physical activity is supposed to decrease mortality of
                      colorectal cancer (CRC) and is suggested to reduce
                      side-effects of the disease and its treatment. However, the
                      knowledge about the influence of exercise interventions on
                      patients suffering from CRC and metastasized CRC (mCRC) is
                      still sparse. One frequently observed side effect in mCRC is
                      chemotherapy-induced peripheral neuropathy (CIPN). This
                      randomized controlled trial investigated the influence of a
                      supervised exercise program on CIPN in mCRC.Thirty patients
                      (stage IV) undergoing outpatient palliative treatment
                      including a median of 23.5 chemotherapy cycles of various
                      regimens were randomly assigned to an intervention or
                      control group (IG, n = 17; CG, n = 13). The IG
                      participated in an eight-week supervised exercise program,
                      including endurance, resistance and balance training
                      (2×/week for 60 min) whereas the CG received written
                      standard recommendations to obtain physical fitness. CIPN
                      was assessed using the FACT/GOG-NTX questionnaire. Moreover,
                      endurance capacity (6MWT), strength (h1RM) and balance
                      (GGT-Reha) were evaluated before (t 0) and after (t 1) the
                      intervention as well as after 4 weeks follow-up
                      (t2).Neuropathic symptoms remained stable in the IG over
                      time, while CIPN significantly worsened in the CG from t 0
                      to t 1 and t 0 to t 2. In contrast to the CG, the IG
                      significantly improved in strength and balance function.
                      Changes in CIPN correlated with changes in balance.This is
                      the first investigation showing positive effects of a
                      multimodal exercise program on CIPN, balance and strength on
                      mCRC patients in a palliative setting, thereby consequently
                      increasing patients` quality of life. The results support
                      earlier findings stating a positive influence of balance
                      exercise on CIPN.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28963591},
      doi          = {10.1007/s00520-017-3875-5},
      url          = {https://inrepo02.dkfz.de/record/131822},
}