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@ARTICLE{Freitag:132437,
      author       = {M. Freitag$^*$ and C. Kesch and J. Cardinale$^*$ and P.
                      Flechsig and R. O. Floca$^*$ and M. Eiber and D.
                      Bonekamp$^*$ and J. P. Radtke and C. Kratochwil and K.
                      Kopka$^*$ and M. Hohenfellner and A. Stenzinger and H.-P.
                      Schlemmer$^*$ and U. Haberkorn$^*$ and F. Giesel$^*$},
      title        = {{S}imultaneous whole-body18{F}-{PSMA}-1007-{PET}/{MRI} with
                      integrated high-resolution multiparametric imaging of the
                      prostatic fossa for comprehensive oncological staging of
                      patients with prostate cancer: a pilot study.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {45},
      number       = {3},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2018-00125},
      pages        = {340 - 347},
      year         = {2018},
      abstract     = {The aim of the present study was to explore the clinical
                      feasibility and reproducibility of a comprehensive
                      whole-body18F-PSMA-1007-PET/MRI protocol for imaging
                      prostate cancer (PC) patients.Eight patients with high-risk
                      biopsy-proven PC underwent a whole-body PET/MRI (3 h p.i.)
                      including a multi-parametric prostate MRI
                      after18F-PSMA-1007-PET/CT (1 h p.i.) which served as
                      reference. Seven patients presented with non-treated PC,
                      whereas one patient presented with biochemical recurrence.
                      SUVmean-quantification was performed using a 3D-isocontour
                      volume-of-interest. Imaging data was consulted for
                      TNM-staging and compared with histopathology. PC was
                      confirmed in 4/7 patients additionally by histopathology
                      after surgery. PET-artifacts, co-registration of pelvic
                      PET/MRI and MRI-data were assessed (PI-RADS 2.0).The
                      examinations were well accepted by patients and comprised
                      1 h. SUVmean-values between PET/CT (1 h p.i.) and PET/MRI
                      (3 h p.i.) were significantly correlated (p < 0.0001,
                      respectively) and similar to literature
                      of18F-PSMA-1007-PET/CT 1 h vs 3 h p.i. The dominant
                      intraprostatic lesion could be detected in all seven
                      patients in both PET and MRI. T2c, T3a, T3b and T4 features
                      were detected complimentarily by PET and MRI in five
                      patients. PET/MRI demonstrated moderate photopenic
                      PET-artifacts surrounding liver and kidneys representing
                      high-contrast areas, no PET-artifacts were observed for
                      PET/CT. Simultaneous PET-readout during prostate MRI
                      achieved optimal co-registration results.The
                      presented18F-PSMA-1007-PET/MRI protocol combines efficient
                      whole-body assessment with high-resolution co-registered
                      PET/MRI of the prostatic fossa for comprehensive oncological
                      staging of patients with PC.},
      cin          = {E010 / E030 / E071 / E060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E030-20160331 /
                      I:(DE-He78)E071-20160331 / I:(DE-He78)E060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29038888},
      doi          = {10.1007/s00259-017-3854-6},
      url          = {https://inrepo02.dkfz.de/record/132437},
}