TY  - JOUR
AU  - Weigl, Korbinian
AU  - Chang-Claude, Jenny
AU  - Knebel, Phillip
AU  - Hsu, Li
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score.
JO  - Clinical epidemiology
VL  - 10
SN  - 1179-1349
CY  - Albany, Auckland
PB  - Dove Medical Press
M1  - DKFZ-2018-00140
SP  - 143 - 152
PY  - 2018
AB  - Family history (FH) and genetic risk scores (GRSs) are increasingly used for risk stratification for colorectal cancer (CRC) screening. However, they were mostly considered alternatively rather than jointly. The aim of this study was to assess the potential of individual and joint risk stratification for CRC by FH and GRS.A GRS was built based on the number of risk alleles in 53 previously identified single-nucleotide polymorphisms among 2,363 patients with a first diagnosis of CRC and 2,198 controls in DACHS [colorectal cancer: chances for prevention through screening], a population-based case-control study in Germany. Associations between GRS and FH with CRC risk were quantified by multiple logistic regression.A total of 316 cases (13.4
LB  - PUB:(DE-HGF)16
C6  - pmid:29403313
C2  - pmc:PMC5783152
DO  - DOI:10.2147/CLEP.S145636
UR  - https://inrepo02.dkfz.de/record/132452
ER  -