TY  - JOUR
AU  - Andersen, Vibeke
AU  - Chan, Simon
AU  - Luben, Robert
AU  - Khaw, Kay-Tee
AU  - Olsen, Anja
AU  - Tjonneland, Anne
AU  - Kaaks, R.
AU  - Grip, Olof
AU  - Bergmann, M. M.
AU  - Boeing, H.
AU  - Hultdin, Johan
AU  - Karling, Pontus
AU  - Overvad, Kim
AU  - Oldenburg, Bas
AU  - Opstelten, Jorrit
AU  - Boutron-Ruault, Marie-Christine
AU  - Carbonnel, Franck
AU  - Racine, Antoine
AU  - Key, Timothy
AU  - Masala, Giovanna
AU  - Palli, Domenico
AU  - Tumino, R.
AU  - Trichopoulou, A.
AU  - Riboli, Elio
AU  - Hart, Andrew
TI  - Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD).
JO  - Journal of Crohn's and Colitis
VL  - 12
IS  - 2
SN  - 1876-4479
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2018-00141
SP  - 129 - 136
PY  - 2018
AB  - Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population.In total, 401326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed.In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29373726
DO  - DOI:10.1093/ecco-jcc/jjx136
UR  - https://inrepo02.dkfz.de/record/132453
ER  -