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@ARTICLE{Andersen:132453,
      author       = {V. Andersen and S. Chan and R. Luben and K.-T. Khaw and A.
                      Olsen and A. Tjonneland and R. Kaaks$^*$ and O. Grip and M.
                      M. Bergmann and H. Boeing and J. Hultdin and P. Karling and
                      K. Overvad and B. Oldenburg and J. Opstelten and M.-C.
                      Boutron-Ruault and F. Carbonnel and A. Racine and T. Key and
                      G. Masala and D. Palli and R. Tumino and A. Trichopoulou and
                      E. Riboli and A. Hart},
      title        = {{F}ibre intake and the development of inflammatory bowel
                      disease: {A} {E}uropean prospective multi-centre cohort
                      study ({EPIC}-{IBD}).},
      journal      = {Journal of Crohn's and Colitis},
      volume       = {12},
      number       = {2},
      issn         = {1876-4479},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2018-00141},
      pages        = {129 - 136},
      year         = {2018},
      abstract     = {Population-based prospective cohort studies investigating
                      fibre intake and development of inflammatory bowel disease
                      are lacking. Our aim was to investigate the association
                      between fibre intake and the development of Crohn's disease
                      [CD] and ulcerative colitis [UC] in a large European
                      population.In total, 401326 participants, aged 20-80 years,
                      were recruited in eight countries in Europe between 1991 and
                      1998. At baseline, fibre intake [total fibres, fibres from
                      fruit, vegetables and cereals] was recorded using food
                      frequency questionnaires. The cohort was monitored for the
                      development of inflammatory bowel disease. Each case was
                      matched with four controls and odds ratios [ORs] for the
                      exposures were calculated using conditional logistic
                      regression. Sensitivity analyses according to smoking status
                      were computed.In total, 104 and 221 participants developed
                      incident CD and UC, respectively. For both CD and UC, there
                      were no statistically significant associations with either
                      quartiles, or trends across quartiles, for total fibre or
                      any of the individual sources. The associations were not
                      affected by adjusting for smoking and energy intake.
                      Stratification according to smoking status showed null
                      findings apart from an inverse association with cereal fibre
                      and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, $95\%$
                      confidence interval = 0.02-0.75, p = 0.023, OR trend across
                      quartiles = 0.50, $95\%$ confidence interval = 0.29-0.86, p
                      = 0.017].The results do not support the hypothesis that
                      dietary fibre is involved in the aetiology of UC, although
                      future work should investigate whether there may be a
                      protective effect of specific types of fibre according to
                      smoking status in CD.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29373726},
      doi          = {10.1093/ecco-jcc/jjx136},
      url          = {https://inrepo02.dkfz.de/record/132453},
}