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@ARTICLE{Dossus:132466,
      author       = {L. Dossus and S. Franceschi and C. Biessy and A.-S.
                      Navionis and R. C. Travis and E. Weiderpass and A. Scalbert
                      and I. Romieu and A. Tjønneland and A. Olsen and K. Overvad
                      and M.-C. Boutron-Ruault and F. Bonnet and A. Fournier and
                      R. Turzanski-Fortner$^*$ and R. Kaaks$^*$ and K.
                      Aleksandrova and A. Trichopoulou and C. La Vecchia and E.
                      Peppa and R. Tumino and S. Panico and D. Palli and C. Agnoli
                      and P. Vineis and H. B. A. Bueno-de-Mesquita and P. H.
                      Peeters and G. Skeie and R. Zamora-Ros and M.-D. Chirlaque
                      and E. Ardanaz and M.-J. Sánchez and J. Ramón Quirós and
                      M. Dorronsoro and M. Sandström and L. M. Nilsson and J. A.
                      Schmidt and K.-T. Khaw and K. K. Tsilidis and D. Aune and E.
                      Riboli and S. Rinaldi},
      title        = {{A}dipokines and inflammation markers and risk of
                      differentiated thyroid carcinoma: {T}he {EPIC} study.},
      journal      = {International journal of cancer},
      volume       = {142},
      number       = {7},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-00154},
      pages        = {1332 - 1342},
      year         = {2018},
      abstract     = {Other than the influence of ionizing radiation and benign
                      thyroid disease, little is known about the risk factors for
                      differentiated thyroid cancer (TC) which is an increasing
                      common cancer worldwide. Consistent evidence shows that body
                      mass is positively associated with TC risk. As excess weight
                      is a state of chronic inflammation, we investigated the
                      relationship between concentrations of leptin, adiponectin,
                      C-reactive protein, interleukin (IL)-6, IL-10 and tumor
                      necrosis factor (TNF)-α and the risk of TC. A case-control
                      study was nested within the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) study and
                      included 475 first primary incident TC cases (399 women and
                      76 men) and 1,016 matched cancer-free cohort participants.
                      Biomarkers were measured in serum samples using validated
                      and highly sensitive commercially available immunoassays.
                      Odds ratios (ORs) of TC by levels of each biomarker were
                      estimated using conditional logistic regression models,
                      adjusting for BMI and alcohol consumption. Adiponectin was
                      inversely associated with TC risk among women
                      (ORT3vs.T1 = 0.69, $95\%$ CI: 0.49-0.98,
                      Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36,
                      $95\%$ CI: 0.67-2.76, Ptrend = 0.37). Increasing levels
                      of IL-10 were positively associated with TC risk in both
                      genders and significantly so in women (ORT3vs.T1 = 1.59,
                      $95\%$ CI: 1.13-2.25, Ptrend = 0.01) but not in men
                      (ORT3vs.T1 = 1.78, $95\%$ CI: 0.80-3.98,
                      Ptrend = 0.17). Leptin, CRP, IL-6 and TNF-α were not
                      associated with TC risk in either gender. These results
                      indicate a positive association of TC risk with IL-10 and a
                      negative association with adiponectin that is probably
                      restricted to women. Inflammation may play a role in TC in
                      combination with or independently of excess weight.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29168186},
      doi          = {10.1002/ijc.31172},
      url          = {https://inrepo02.dkfz.de/record/132466},
}