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| Home > Publications database > Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort. > print |
| Home > Publications database > Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort. > print |
| 001 | 132470 | ||
| 005 | 20240229105018.0 | ||
| 024 | 7 | _ | |a 10.1002/ijc.31164 |2 doi |
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| 100 | 1 | _ | |a Fortner, Renée T |0 0000-0002-1426-8505 |b 0 |e First author |
| 245 | _ | _ | |a Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort. |
| 260 | _ | _ | |a Bognor Regis |c 2018 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti-CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76-0.92]; lowest tertile: 0.76 [0.67-0.86]; phet = 0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti-CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection. |
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| 700 | 1 | _ | |a Schock, Helena |0 P:(DE-He78)1bd6298f721e4a01f21c2329276a53a7 |b 1 |u dkfz |
| 700 | 1 | _ | |a Le Cornet, Charlotte |0 P:(DE-He78)2d4cac0f4bf270325b98fe07036dc6c6 |b 2 |u dkfz |
| 700 | 1 | _ | |a Hüsing, Anika |0 P:(DE-He78)6519c85d61a3def7974665471b8a4f74 |b 3 |u dkfz |
| 700 | 1 | _ | |a Vitonis, Allison F |b 4 |
| 700 | 1 | _ | |a Johnson, Theron S |b 5 |
| 700 | 1 | _ | |a Fichorova, Raina N |b 6 |
| 700 | 1 | _ | |a Fashemi, Titilayo |b 7 |
| 700 | 1 | _ | |a Yamamoto, Hidemi S |b 8 |
| 700 | 1 | _ | |a Tjønneland, Anne |b 9 |
| 700 | 1 | _ | |a Hansen, Louise |b 10 |
| 700 | 1 | _ | |a Overvad, Kim |b 11 |
| 700 | 1 | _ | |a Boutron-Ruault, Marie-Christine |b 12 |
| 700 | 1 | _ | |a Kvaskoff, Marina |b 13 |
| 700 | 1 | _ | |a Severi, Gianluca |b 14 |
| 700 | 1 | _ | |a Boeing, Heiner |b 15 |
| 700 | 1 | _ | |a Trichopoulou, Antonia |b 16 |
| 700 | 1 | _ | |a Papatesta, Eleni-Maria |b 17 |
| 700 | 1 | _ | |a La Vecchia, Carlo |0 0000-0003-1441-897X |b 18 |
| 700 | 1 | _ | |a Palli, Domenico |0 0000-0002-5558-2437 |b 19 |
| 700 | 1 | _ | |a Sieri, Sabina |b 20 |
| 700 | 1 | _ | |a Tumino, Rosario |b 21 |
| 700 | 1 | _ | |a Sacerdote, Carlotta |0 0000-0002-8008-5096 |b 22 |
| 700 | 1 | _ | |a Mattiello, Amalia |b 23 |
| 700 | 1 | _ | |a Onland-Moret, N Charlotte |b 24 |
| 700 | 1 | _ | |a Peeters, Petra H |b 25 |
| 700 | 1 | _ | |a Bueno-de-Mesquita, H B As |b 26 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |b 27 |
| 700 | 1 | _ | |a Quirós, J Ramón |b 28 |
| 700 | 1 | _ | |a Duell, Eric J |0 0000-0001-5256-0163 |b 29 |
| 700 | 1 | _ | |a Sánchez, Maria-Jose |b 30 |
| 700 | 1 | _ | |a Navarro, Carmen |b 31 |
| 700 | 1 | _ | |a Ardanaz, Eva |b 32 |
| 700 | 1 | _ | |a Larrañaga, Nerea |b 33 |
| 700 | 1 | _ | |a Nodin, Björn |b 34 |
| 700 | 1 | _ | |a Jirström, Karin |b 35 |
| 700 | 1 | _ | |a Idahl, Annika |b 36 |
| 700 | 1 | _ | |a Lundin, Eva |b 37 |
| 700 | 1 | _ | |a Khaw, Kay-Tee |b 38 |
| 700 | 1 | _ | |a Travis, Ruth C |b 39 |
| 700 | 1 | _ | |a Gunter, Marc |b 40 |
| 700 | 1 | _ | |a Johansson, Mattias |b 41 |
| 700 | 1 | _ | |a Dossus, Laure |b 42 |
| 700 | 1 | _ | |a Merritt, Melissa A |b 43 |
| 700 | 1 | _ | |a Riboli, Elio |b 44 |
| 700 | 1 | _ | |a Terry, Kathryn L |b 45 |
| 700 | 1 | _ | |a Cramer, Daniel W |b 46 |
| 700 | 1 | _ | |a Kaaks, Rudolf |0 0000-0003-3751-3929 |b 47 |e Last author |
| 773 | _ | _ | |a 10.1002/ijc.31164 |g Vol. 142, no. 7, p. 1355 - 1360 |0 PERI:(DE-600)1474822-8 |n 7 |p 1355 - 1360 |t International journal of cancer |v 142 |y 2018 |x 0020-7136 |
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