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@ARTICLE{Funck:132471,
      author       = {C. Funck$^*$ and F. B. Laun$^*$ and A. Wetscherek$^*$},
      title        = {{C}haracterization of the diffusion coefficient of blood.},
      journal      = {Magnetic resonance in medicine},
      volume       = {79},
      number       = {5},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-00159},
      pages        = {2752 - 2758},
      year         = {2018},
      abstract     = {To characterize the diffusion coefficient of human blood
                      for accurate results in intravoxel incoherent motion
                      imaging.Diffusion-weighted MRI of blood samples from 10
                      healthy volunteers was acquired with a single-shot
                      echo-planar-imaging sequence at body temperature. Effects of
                      gradient profile (monopolar or flow-compensated), diffusion
                      time (40-100 ms), and echo time (60-200 ms) were
                      investigated.Although measured apparent diffusion
                      coefficients of blood were larger for flow-compensated than
                      for monopolar gradients, no dependence of the apparent
                      diffusion coefficient on the diffusion time was found. Large
                      differences between individual samples were observed, with
                      results ranging from 1.26 to 1.66 µm2/ms for
                      flow-compensated and 0.94 to 1.52 µm2/ms for monopolar
                      gradients. Statistical analysis indicates correlations of
                      the flow-compensated apparent diffusion coefficient with
                      hematocrit (P = 0.007) and hemoglobin (P = 0.017),
                      but not with mean corpuscular volume (P = 0.64). Results
                      of Monte-Carlo simulations support the experimental
                      observations.Measured blood apparent diffusion coefficient
                      values depend on hematocrit/hemoglobin concentration and
                      applied gradient profile due to non-Gaussian diffusion.
                      Because in vivo measurement is delicate, an estimation based
                      on blood count results could be an alternative. For
                      intravoxel incoherent motion modeling, the use of a blood
                      self-diffusion constant Db = 1.54 ± 0.12 µm2/ms
                      for flow-compensated and Db = 1.30 ± 0.18 µm2/ms
                      for monopolar encoding is suggested. Magn Reson Med
                      79:2752-2758, 2018. © 2017 The Authors Magnetic Resonance
                      in Medicine published by Wiley Periodicals, Inc. on behalf
                      of International Society for Magnetic Resonance in Medicine.
                      This is an open access article under the terms of the
                      Creative Commons Attribution License, which permits use,
                      distribution and reproduction in any medium, provided the
                      original work is properly cited.},
      cin          = {E020 / E025},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E025-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28940621},
      doi          = {10.1002/mrm.26919},
      url          = {https://inrepo02.dkfz.de/record/132471},
}