TY  - JOUR
AU  - Jones, David
AU  - Kieran, Mark W
AU  - Bouffet, Eric
AU  - Alexandrescu, Sanda
AU  - Bandopadhayay, Pratiti
AU  - Bornhorst, Miriam
AU  - Ellison, David
AU  - Fangusaro, Jason
AU  - Fisher, Michael J
AU  - Foreman, Nicholas
AU  - Fouladi, Maryam
AU  - Hargrave, Darren
AU  - Hawkins, Cynthia
AU  - Jabado, Nada
AU  - Massimino, Maura
AU  - Mueller, Sabine
AU  - Perilongo, Giorgio
AU  - Schouten van Meeteren, Antoinette Y N
AU  - Tabori, Uri
AU  - Warren, Katherine
AU  - Waanders, Angela J
AU  - Walker, David
AU  - Weiss, William
AU  - Witt, Olaf
AU  - Wright, Karen
AU  - Zhu, Yuan
AU  - Bowers, Daniel C
AU  - Pfister, Stefan
AU  - Packer, Roger J
TI  - Pediatric low-grade gliomas: next biologically driven steps.
JO  - Neuro-Oncology
VL  - 20
IS  - 2
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2018-00172
SP  - 160 - 173
PY  - 2018
AB  - Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain a significant clinical challenge in pediatric neuro-oncology due to comorbidities associated with these tumors and/or their treatments, and their propensity to multiply recurs. LGGs, in total the most common brain tumors arising in childhood, can often become a chronic problem requiring decades of management. The Second International Consensus Conference on Pediatric Low-Grade Gliomas held in Padua, Italy in 2016 was convened in an attempt to advance the pace of translating biological discoveries on LGGs into meaningful clinical benefit. Topics discussed included: the implications of our growing biological understanding of the genomics underlying these tumors; the assessment of the model systems available; the implications of the molecular and histopathologic differences between adult and pediatric diffuse gliomas; and steps needed to expedite targeted therapy into late-stage clinical trials for newly diagnosed cases. Methods for the diagnostic assessment of alterations in the Ras/mitogen-activated protein kinase pathway, typical for these tumors, were also considered. While the overall tone was positive, with a consensus that progress is being and will continue to be made, the scale of the challenge presented by this complex group of tumors was also acknowledged. The conclusions and recommendations of the meeting panel are provided here as an outline of current thinking and a basis for further discussion.
LB  - PUB:(DE-HGF)16
C6  - pmid:29016845
C2  - pmc:PMC5786244
DO  - DOI:10.1093/neuonc/nox141
UR  - https://inrepo02.dkfz.de/record/132485
ER  -