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@ARTICLE{Laader:132493,
      author       = {A. Laader and K. Beiderwellen and O. Kraff and S. Maderwald
                      and M. Ladd$^*$ and M. Forsting and L. Umutlu},
      title        = {{N}on-enhanced versus low-dose contrast-enhanced renal
                      magnetic resonance angiography at 7 {T}: a feasibility
                      study.},
      journal      = {Acta radiologica},
      volume       = {59},
      number       = {3},
      issn         = {1600-0455},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DKFZ-2018-00180},
      pages        = {296 - 304},
      year         = {2018},
      abstract     = {Background Considering the currently reported association
                      between a repetitive application and cumulative dosage of
                      Gadolinium (Gd)-based contrast agents and Gd-deposition in
                      brain tissue as well as the risk for the advent of
                      nephrogenic systemic fibrosis (NSF), techniques allowing for
                      a dose reduction become an important key aspect aside from
                      non-enhanced magnetic resonance angiography (MRA)
                      techniques. Thus, this study was focused on the reduction
                      and/or complete omission of contrast agent for renal MRA at
                      7T. Purpose To evaluate the performance of time-of-flight
                      MRA versus low-dose contrast-enhanced (CE) renal MRA at 7T.
                      Material and Methods Ten healthy volunteers were examined on
                      a 7T MR system comprising a TOF MRA and three-dimensional
                      (3D) fast low angle shot spoiled gradient-echo sequence
                      (FLASH) MRA after administration of one-quarter of clinical
                      dose of gadobutrol. Qualitative image analysis was performed
                      including overall image quality, artery delineation and
                      presence of artifacts. Contrast ratio (CR), signal-to-noise
                      ratio (SNR), and contrast-to-noise ratio (CNR) of the renal
                      arteries were calculated. Results TOF MRA and low-CE MRA
                      achieved comparable overall ratings, with slightly superior
                      delineation of the main renal arteries in TOF MRA
                      (TOF = 3.10 ± 0.75, low-CE = 2.95 ± 0.75).
                      Segmental branches outside and inside the parenchyma were
                      delineated significantly better on TOF MRA. Quantitative
                      analysis demonstrated the superiority of TOF MRA, yielding
                      higher scores for CR, SNR, and CNR. Conclusion The initial
                      results of our study demonstrate the feasibility and
                      comparable diagnostic performance of TOF and low-dose CE
                      renal MRA at 7T.},
      keywords     = {Contrast Media (NLM Chemicals)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28691526},
      doi          = {10.1177/0284185117718399},
      url          = {https://inrepo02.dkfz.de/record/132493},
}