%0 Journal Article
%A Lassale, Camille
%A Tzoulaki, Ioanna
%A Moons, Karel G M
%A Sweeting, Michael
%A Boer, Jolanda
%A Johnson, Laura
%A Huerta, José María
%A Agnoli, Claudia
%A Freisling, Heinz
%A Weiderpass, Elisabete
%A Wennberg, Patrik
%A van der A, Daphne L
%A Arriola, Larraitz
%A Benetou, Vassiliki
%A Boeing, Heiner
%A Bonnet, Fabrice
%A Colorado-Yohar, Sandra M
%A Engström, Gunnar
%A Eriksen, Anne K
%A Ferrari, Pietro
%A Grioni, Sara
%A Johansson, Matthias
%A Kaaks, Rudolf
%A Katsoulis, Michail
%A Katzke, Verena
%A Key, Timothy J
%A Matullo, Giuseppe
%A Melander, Olle
%A Molina-Portillo, Elena
%A Moreno-Iribas, Concepción
%A Norberg, Margareta
%A Overvad, Kim
%A Panico, Salvatore
%A Quirós, J Ramón
%A Saieva, Calogero
%A Skeie, Guri
%A Steffen, Annika
%A Stepien, Magdalena
%A Tjønneland, Anne
%A Trichopoulou, Antonia
%A Tumino, Rosario
%A van der Schouw, Yvonne T
%A Verschuren, W M Monique
%A Langenberg, Claudia
%A Di Angelantonio, Emanuele
%A Riboli, Elio
%A Wareham, Nicholas J
%A Danesh, John
%A Butterworth, Adam S
%T Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis.
%J European heart journal
%V 39
%N 5
%@ 1522-9645
%C Oxford
%I Oxford University Press
%M DKFZ-2018-00181
%P 397 - 406
%D 2018
%X The hypothesis of metabolically healthy obesity implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk. We tested this hypothesis in a large pan-European prospective study.We conducted a case-cohort analysis in the 520 000-person European Prospective Investigation into Cancer and Nutrition study (EPIC-CVD). During a median follow-up of 12.2 years, we recorded 7637 incident coronary heart disease (CHD) cases. Using cut-offs recommended by guidelines, we defined obesity and overweight using body mass index (BMI), and metabolic dysfunction (unhealthy) as ≥ 3 of elevated blood pressure, hypertriglyceridaemia, low HDL-cholesterol, hyperglycaemia, and elevated waist circumference. We calculated hazard ratios (HRs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29020414
%R 10.1093/eurheartj/ehx448
%U https://inrepo02.dkfz.de/record/132494