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@ARTICLE{Lu:132497,
      author       = {D.-L. Lu$^*$ and D. Sookthai$^*$ and C. Le Cornet$^*$ and
                      V. Katzke$^*$ and T. S. Johnson$^*$ and R. Kaaks$^*$ and R.
                      Turzanski-Fortner$^*$},
      title        = {{R}eproducibility of serum oxysterols and lanosterol among
                      postmenopausal women: {R}esults from {EPIC}-{H}eidelberg.},
      journal      = {Clinical biochemistry},
      volume       = {52},
      issn         = {0009-9120},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-00184},
      pages        = {117 - 122},
      year         = {2018},
      abstract     = {Circulating oxysterols have been proposed as biological
                      markers of disease risk. However, within-person
                      reproducibility of circulating oxysterols over time is not
                      well established.We evaluated the one-year reproducibility
                      of 11 oxysterols and lanosterol among 30 postmenopausal
                      women with repeat blood samples in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) - Heidelberg,
                      Germany cohort. Liquid chromatography-mass spectrometry
                      (LC/MS) was performed to quantify serum concentrations of
                      22R-hydroxycholesterol, 25-hydroxycholesterol,
                      24S-hydroxycholesterol, 27-hydroxycholesterol,
                      22S-hydroxycholeterol, 24,25-epoxycholesterol,
                      5α,6β-dihydroxycholestanol, 7α-hydroxycholesterol,
                      5β,6β-epoxycholesterol, 5α,6α-epoxycholesterol,
                      24-dihydrolanosterol, and lanosterol. We evaluated Spearman
                      correlations and intraclass correlation coefficients (ICCs)
                      between quantifiable concentrations measured in repeat
                      samples taken one-year apart to estimate within-person
                      reproducibility.Spearman correlations (ICCs) over one year
                      ranged from 0 (ICC=0.10) for 5β,6β-epoxycholesterol and
                      0.10 (ICC=0.20) for 5α,6α-epoxycholesterol, representing
                      low within-person stability, to 0.81 (ICC=0.75) for
                      27-hydroxycholesterol and 0.86 (ICC=0.91) for
                      24S-hydroxycholesterol, representing relatively high
                      within-person stability. Correlations between oxysterols and
                      lanosterol ranged from 0.01 between 24S-hydroxycholesterol
                      and lanosterol to 0.70 between 5α,6α-epoxycholesterol and
                      5β,6β-epoxycholesterol.Our results demonstrate that for
                      27-hydroxycholesterol, 24S-hydroxycholesterol,
                      25-hydroxycholesterol, 7α-hydroxycholesterol and
                      lanosterol, a single serum measurement can reliably estimate
                      average levels over a one-year period. Circulating
                      oxysterols are of increasing interest in epidemiologic
                      studies of chronic disease risk including cancer and
                      cardiovascular disease. Our data suggest that within-person
                      stability of oxysterols differs depending on the individual
                      oxysterol evaluated. We identified four oxysterols and
                      lanosterol as stable over time to inform the use of
                      circulating oxysterols in epidemiologic studies.},
      cin          = {C020},
      ddc          = {540},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29108727},
      doi          = {10.1016/j.clinbiochem.2017.11.001},
      url          = {https://inrepo02.dkfz.de/record/132497},
}