TY  - JOUR
AU  - Mosebach, Jennifer
AU  - Shah, Sofia
AU  - Delorme, Stefan
AU  - Hielscher, Thomas
AU  - Goldschmidt, Hartmut
AU  - Schlemmer, Heinz-Peter
AU  - Schönland, Stefan
AU  - Hegenbart, Ute
AU  - Hillengass, Jens
TI  - Prognostic significance of tumor burden assessed by whole-body magnetic resonance imaging in multiple myeloma patients treated with allogeneic stem cell transplantation.
JO  - Haematologica
VL  - 103
IS  - 2
SN  - 1592-8721
CY  - Pavia
PB  - Ferrata Storti Foundation
M1  - DKFZ-2018-00188
SP  - 336 - 343
PY  - 2018
AB  - Allogeneic stem cell transplantation is a therapeutic option under dispute but nonetheless chosen with increasing frequency for patients suffering from multiple myeloma in Europe. To study possible predictors of survival, 79 patients were investigated using whole-body magnetic resonance imaging to assess the visible tumor burden before and after allogeneic stem cell transplantation. Statistical analysis of clinical and imaging parameters included Cox regression models and distribution of survival time estimates (Kaplan-Meier method). Log rank test was used to determine the prognostic impact of the presence of focal lesions on survival. A higher tumor burden according to the lesion count was associated with a shorter overall survival (univariable/multivariable Cox regression: 1stmagnetic resonance imagingP=0.028/P=0.048; 2ndmagnetic resonance imagingP=0.008/P=0.024). Focal infiltration pattern itself seemed to be an additional adverse prognostic factor for overall survival (2ndMRIP=0.048), although no definite cut-off could be defined. Kaplan-Meier estimates at 60 months of follow up show a significant difference (Log rankP=0.04) for overall survival rates between patients with focal infiltration (32
LB  - PUB:(DE-HGF)16
C6  - pmid:29217779
C2  - pmc:PMC5792278
DO  - DOI:10.3324/haematol.2017.176073
UR  - https://inrepo02.dkfz.de/record/132501
ER  -