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@ARTICLE{Mosebach:132501,
      author       = {J. Mosebach$^*$ and S. Shah and S. Delorme$^*$ and T.
                      Hielscher$^*$ and H. Goldschmidt and H.-P. Schlemmer$^*$ and
                      S. Schönland and U. Hegenbart and J. Hillengass},
      title        = {{P}rognostic significance of tumor burden assessed by
                      whole-body magnetic resonance imaging in multiple myeloma
                      patients treated with allogeneic stem cell transplantation.},
      journal      = {Haematologica},
      volume       = {103},
      number       = {2},
      issn         = {1592-8721},
      address      = {Pavia},
      publisher    = {Ferrata Storti Foundation},
      reportid     = {DKFZ-2018-00188},
      pages        = {336 - 343},
      year         = {2018},
      abstract     = {Allogeneic stem cell transplantation is a therapeutic
                      option under dispute but nonetheless chosen with increasing
                      frequency for patients suffering from multiple myeloma in
                      Europe. To study possible predictors of survival, 79
                      patients were investigated using whole-body magnetic
                      resonance imaging to assess the visible tumor burden before
                      and after allogeneic stem cell transplantation. Statistical
                      analysis of clinical and imaging parameters included Cox
                      regression models and distribution of survival time
                      estimates (Kaplan-Meier method). Log rank test was used to
                      determine the prognostic impact of the presence of focal
                      lesions on survival. A higher tumor burden according to the
                      lesion count was associated with a shorter overall survival
                      (univariable/multivariable Cox regression: 1stmagnetic
                      resonance imagingP=0.028/P=0.048; 2ndmagnetic resonance
                      imagingP=0.008/P=0.024). Focal infiltration pattern itself
                      seemed to be an additional adverse prognostic factor for
                      overall survival (2ndMRIP=0.048), although no definite
                      cut-off could be defined. Kaplan-Meier estimates at 60
                      months of follow up show a significant difference (Log
                      rankP=0.04) for overall survival rates between patients with
                      focal infiltration $(32\%)$ and those without $(75\%).$
                      Since this subgroup of patients may benefit from maintenance
                      therapy, adoptive immunotherapy, or local interventions,
                      whole-body imaging is an appropriate and highly
                      recommendable diagnostic approach for detection of
                      prognostically relevant lesions before and after treatment.},
      cin          = {E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29217779},
      pmc          = {pmc:PMC5792278},
      doi          = {10.3324/haematol.2017.176073},
      url          = {https://inrepo02.dkfz.de/record/132501},
}