TY  - JOUR
AU  - Ordóñez-Mena, J. M.
AU  - Walter, V.
AU  - Schöttker, B.
AU  - Jenab, M.
AU  - O'Doherty, M. G.
AU  - Kee, F.
AU  - Bueno-de-Mesquita, B.
AU  - Peeters, P. H. M.
AU  - Stricker, B. H.
AU  - Ruiter, R.
AU  - Hofman, A.
AU  - Söderberg, S.
AU  - Jousilahti, P.
AU  - Kuulasmaa, K.
AU  - Freedman, N. D.
AU  - Wilsgaard, T.
AU  - Wolk, A.
AU  - Nilsson, L. M.
AU  - Tjønneland, A.
AU  - Quirós, J. R.
AU  - van Duijnhoven, F. J. B.
AU  - Siersema, P. D.
AU  - Boffetta, P.
AU  - Trichopoulou, A.
AU  - Brenner, Hermann
TI  - Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium.
JO  - Annals of oncology
VL  - 29
IS  - 2
SN  - 1569-8041
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2018-00190
SP  - 472 - 483
PY  - 2018
AB  - Smoking has been associated with colorectal cancer (CRC) incidence and mortality in previous studies and might also be associated with prognosis after CRC diagnosis. However, current evidence on smoking in association with CRC prognosis is limited.For this individual patient data meta-analysis, sociodemographic and smoking behavior information of 12 414 incident CRC patients (median age at diagnosis: 64.3 years), recruited within 14 prospective cohort studies among previously cancer-free adults, was collected at baseline and harmonized across studies. Vital status and causes of death were collected for a mean follow-up time of 5.1 years following cancer diagnosis. Associations of smoking behavior with overall and CRC-specific survival were evaluated using Cox regression and standard meta-analysis methodology.A total of 5229 participants died, 3194 from CRC. Cox regression revealed significant associations between former [hazard ratio (HR) = 1.12; 95 
LB  - PUB:(DE-HGF)16
C6  - pmid:29244072
DO  - DOI:10.1093/annonc/mdx761
UR  - https://inrepo02.dkfz.de/record/132503
ER  -