TY  - JOUR
AU  - Schroeder, Lea
AU  - Wichmann, Gunnar
AU  - Willner, Maria
AU  - Michel, Angelika
AU  - Wiesenfarth, Manuel
AU  - Flechtenmacher, Christa
AU  - Gradistanac, Tanja
AU  - Pawlita, Michael
AU  - Dietz, Andreas
AU  - Waterboer, Tim
AU  - Holzinger, Dana
TI  - Antibodies against human papillomaviruses as diagnostic and prognostic biomarker in patients with neck squamous cell carcinoma from unknown primary tumor.
JO  - International journal of cancer
VL  - 142
IS  - 7
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2018-00200
SP  - 1361 - 1368
PY  - 2018
AB  - Treatment of patients with neck lymph node metastasis of squamous cell carcinoma (SCC) from unknown primary tumor (NSCCUP) is challenging due to the risk of missing occult tumors or inducing toxicity to unaffected sites. Human papillomavirus (HPV) is a promising biomarker given its causal link to oropharyngeal SCC and superior survival of patients with HPV-driven oropharyngeal SCC and NSCCUP. Identification of HPV-driven NSCCUP could focus diagnostic work-up and treatment on the oropharynx. For the first time, we assessed HPV antibodies and their prognostic value in NSCCUP patients. Antibodies against E6 and E7 (HPV16/18/31/33/35), E1 and E2 (HPV16/18) were assessed in 46 NSCCUP patients in sera collected at diagnosis, and in follow-up sera from five patients. In 28 patients, HPV tumor status was determined using molecular markers (HPV DNA, mRNA and cellular p16INK4a). Thirteen (28
LB  - PUB:(DE-HGF)16
C6  - pmid:29159804
DO  - DOI:10.1002/ijc.31167
UR  - https://inrepo02.dkfz.de/record/132513
ER  -