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@ARTICLE{Vermeulen:132521,
      author       = {J. F. Vermeulen and W. Van Hecke and E. J. M. Adriaansen
                      and M. K. Jansen and R. G. Bouma and J. Villacorta Hidalgo
                      and P. Fisch and R. Broekhuizen and W. G. M. Spliet and M.
                      Kool$^*$ and N. Bovenschen},
      title        = {{P}rognostic relevance of tumor-infiltrating lymphocytes
                      and immune checkpoints in pediatric medulloblastoma.},
      journal      = {OncoImmunology},
      volume       = {7},
      number       = {3},
      issn         = {2162-402X},
      address      = {Austin, Tex.},
      publisher    = {Landes Bioscience},
      reportid     = {DKFZ-2018-00207},
      pages        = {e1398877 -},
      year         = {2018},
      abstract     = {Pediatric medulloblastomas are the most frequently
                      diagnosed embryonal tumors of the central nervous system.
                      Current therapies cause severe neurological and cognitive
                      side effects including secondary malignancies. Cellular
                      immunotherapy might be key to improve survival and to avoid
                      morbidity. Efficient killing of tumor cells using
                      immunotherapy requires to overcome cancer-associated
                      strategies to evade cytotoxic immune responses. Here, we
                      examined the immune response and immune evasion strategies
                      in pediatric medulloblastomas. Cytotoxic T-cells,
                      infiltrating medulloblastomas with variable activation
                      status, showed no correlation with overall survival of the
                      patients. We found limited numbers of PD1+T-cells and
                      complete absence of PD-L1 on medulloblastomas.
                      Medulloblastomas downregulated immune recognition molecules
                      MHC-I and CD1 d. Intriguingly, expression of granzyme
                      inhibitors SERPINB1 and SERPINB4 was acquired in $23\%$ and
                      $50\%$ of the tumors, respectively. Concluding, pediatric
                      medulloblastomas exploit multiple immune evasion strategies
                      to overcome immune surveillance. Absence of PD-L1 expression
                      in medulloblastoma suggest limited or no added value for
                      immunotherapy with PD1/PD-L1 blockers.},
      cin          = {B062 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29399402},
      pmc          = {pmc:PMC5790383},
      doi          = {10.1080/2162402X.2017.1398877},
      url          = {https://inrepo02.dkfz.de/record/132521},
}