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@ARTICLE{Vanner:132541,
      author       = {R. J. Vanner and M. Remke and M. Gallo and H. J. Selvadurai
                      and F. Coutinho and L. Lee and M. Kushida and R. Head and S.
                      Morrissy and X. Zhu and T. Aviv and V. Voisin and I. D.
                      Clarke and Y. Li and A. J. Mungall and R. A. Moore and Y. Ma
                      and S. J. M. Jones and M. A. Marra and D. Malkin and P. A.
                      Northcott and M. Kool$^*$ and S. Pfister$^*$ and G. Bader
                      and K. Hochedlinger and A. Korshunov$^*$ and M. D. Taylor
                      and P. B. Dirks},
      title        = {{Q}uiescent sox2(+) cells drive hierarchical growth and
                      relapse in sonic hedgehog subgroup medulloblastoma.},
      journal      = {Cancer cell},
      volume       = {26},
      number       = {1},
      issn         = {1535-6108},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2018-00223},
      pages        = {33 - 47},
      year         = {2014},
      abstract     = {Functional heterogeneity within tumors presents a
                      significant therapeutic challenge. Here we show that
                      quiescent, therapy-resistant Sox2(+) cells propagate sonic
                      hedgehog subgroup medulloblastoma by a mechanism that
                      mirrors a neurogenic program. Rare Sox2(+) cells produce
                      rapidly cycling doublecortin(+) progenitors that, together
                      with their postmitotic progeny expressing NeuN, comprise
                      tumor bulk. Sox2(+) cells are enriched following
                      anti-mitotic chemotherapy and Smoothened inhibition,
                      creating a reservoir for tumor regrowth. Lineage traces from
                      Sox2(+) cells increase following treatment, suggesting that
                      this population is responsible for relapse. Targeting
                      Sox2(+) cells with the antineoplastic mithramycin abrogated
                      tumor growth. Addressing functional heterogeneity and
                      eliminating Sox2(+) cells presents a promising therapeutic
                      paradigm for treatment of sonic hedgehog subgroup
                      medulloblastoma.},
      keywords     = {Antigens, Nuclear (NLM Chemicals) / Antineoplastic Agents
                      (NLM Chemicals) / Biomarkers, Tumor (NLM Chemicals) /
                      Hedgehog Proteins (NLM Chemicals) / Microtubule-Associated
                      Proteins (NLM Chemicals) / Nerve Tissue Proteins (NLM
                      Chemicals) / NeuN protein, mouse (NLM Chemicals) /
                      Neuropeptides (NLM Chemicals) / Nuclear Proteins (NLM
                      Chemicals) / Patched Receptors (NLM Chemicals) / Receptors,
                      Cell Surface (NLM Chemicals) / Receptors, G-Protein-Coupled
                      (NLM Chemicals) / SHH protein, human (NLM Chemicals) / SMO
                      protein, human (NLM Chemicals) / SOX2 protein, human (NLM
                      Chemicals) / SOXB1 Transcription Factors (NLM Chemicals) /
                      Shh protein, mouse (NLM Chemicals) / Smo protein, mouse (NLM
                      Chemicals) / Smoothened Receptor (NLM Chemicals) / Sox2
                      protein, mouse (NLM Chemicals) / doublecortin protein (NLM
                      Chemicals) / neuronal nuclear antigen NeuN, human (NLM
                      Chemicals) / Plicamycin (NLM Chemicals)},
      cin          = {B062 / G380},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)G380-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24954133},
      pmc          = {pmc:PMC4441014},
      doi          = {10.1016/j.ccr.2014.05.005},
      url          = {https://inrepo02.dkfz.de/record/132541},
}