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| Home > Publications database > Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. > print |
| Home > Publications database > Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. > print |
| 001 | 132541 | ||
| 005 | 20240228135110.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccr.2014.05.005 |2 doi |
| 024 | 7 | _ | |a pmid:24954133 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4441014 |2 pmc |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 024 | 7 | _ | |a altmetric:2449834 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-00223 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Vanner, Robert J |b 0 |
| 245 | _ | _ | |a Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2014 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1520341977_24409 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. Rare Sox2(+) cells produce rapidly cycling doublecortin(+) progenitors that, together with their postmitotic progeny expressing NeuN, comprise tumor bulk. Sox2(+) cells are enriched following anti-mitotic chemotherapy and Smoothened inhibition, creating a reservoir for tumor regrowth. Lineage traces from Sox2(+) cells increase following treatment, suggesting that this population is responsible for relapse. Targeting Sox2(+) cells with the antineoplastic mithramycin abrogated tumor growth. Addressing functional heterogeneity and eliminating Sox2(+) cells presents a promising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antigens, Nuclear |2 NLM Chemicals |
| 650 | _ | 7 | |a Antineoplastic Agents |2 NLM Chemicals |
| 650 | _ | 7 | |a Biomarkers, Tumor |2 NLM Chemicals |
| 650 | _ | 7 | |a Hedgehog Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Microtubule-Associated Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Nerve Tissue Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a NeuN protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Neuropeptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Nuclear Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Patched Receptors |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Cell Surface |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, G-Protein-Coupled |2 NLM Chemicals |
| 650 | _ | 7 | |a SHH protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a SMO protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a SOX2 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a SOXB1 Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Shh protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Smo protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Smoothened Receptor |2 NLM Chemicals |
| 650 | _ | 7 | |a Sox2 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a doublecortin protein |2 NLM Chemicals |
| 650 | _ | 7 | |a neuronal nuclear antigen NeuN, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Plicamycin |0 NIJ123W41V |2 NLM Chemicals |
| 700 | 1 | _ | |a Remke, Marc |b 1 |
| 700 | 1 | _ | |a Gallo, Marco |b 2 |
| 700 | 1 | _ | |a Selvadurai, Hayden J |b 3 |
| 700 | 1 | _ | |a Coutinho, Fiona |b 4 |
| 700 | 1 | _ | |a Lee, Lilian |b 5 |
| 700 | 1 | _ | |a Kushida, Michelle |b 6 |
| 700 | 1 | _ | |a Head, Renee |b 7 |
| 700 | 1 | _ | |a Morrissy, Sorana |b 8 |
| 700 | 1 | _ | |a Zhu, Xueming |b 9 |
| 700 | 1 | _ | |a Aviv, Tzvi |b 10 |
| 700 | 1 | _ | |a Voisin, Veronique |b 11 |
| 700 | 1 | _ | |a Clarke, Ian D |b 12 |
| 700 | 1 | _ | |a Li, Yisu |b 13 |
| 700 | 1 | _ | |a Mungall, Andrew J |b 14 |
| 700 | 1 | _ | |a Moore, Richard A |b 15 |
| 700 | 1 | _ | |a Ma, Yussanne |b 16 |
| 700 | 1 | _ | |a Jones, Steven J M |b 17 |
| 700 | 1 | _ | |a Marra, Marco A |b 18 |
| 700 | 1 | _ | |a Malkin, David |b 19 |
| 700 | 1 | _ | |a Northcott, Paul A |0 P:(DE-HGF)0 |b 20 |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 21 |u dkfz |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 22 |u dkfz |
| 700 | 1 | _ | |a Bader, Gary |b 23 |
| 700 | 1 | _ | |a Hochedlinger, Konrad |b 24 |
| 700 | 1 | _ | |a Korshunov, Andrey |0 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |b 25 |u dkfz |
| 700 | 1 | _ | |a Taylor, Michael D |b 26 |
| 700 | 1 | _ | |a Dirks, Peter B |b 27 |
| 773 | _ | _ | |a 10.1016/j.ccr.2014.05.005 |g Vol. 26, no. 1, p. 33 - 47 |0 PERI:(DE-600)2074034-7 |n 1 |p 33 - 47 |t Cancer cell |v 26 |y 2014 |x 1535-6108 |
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