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000132547 0247_ $$2doi$$a10.1016/j.jneuroim.2017.12.001
000132547 0247_ $$2pmid$$apmid:29224960
000132547 0247_ $$2ISSN$$a0165-5728
000132547 0247_ $$2ISSN$$a1872-8421
000132547 037__ $$aDKFZ-2018-00225
000132547 041__ $$aeng
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000132547 1001_ $$aBansi, Jens$$b0
000132547 245__ $$aPersons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training.
000132547 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2018
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000132547 520__ $$aDisturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS. Further research is warranted to investigate whether these changes are associated with clinical measures (e.g. depressions and immune function).
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000132547 7001_ $$aKoliamitra, Christina$$b1
000132547 7001_ $$aBloch, Wilhelm$$b2
000132547 7001_ $$aJoisten, Niklas$$b3
000132547 7001_ $$aSchenk, Alexander$$b4
000132547 7001_ $$aWatson, Matthew$$b5
000132547 7001_ $$aKool, Jan$$b6
000132547 7001_ $$aLangdon, Dawn$$b7
000132547 7001_ $$aDalgas, Ulrik$$b8
000132547 7001_ $$aKesselring, Jürg$$b9
000132547 7001_ $$0P:(DE-He78)d05b24af674d8ef2c455634434b67770$$aZimmer, Philipp$$b10$$eLast author$$udkfz
000132547 773__ $$0PERI:(DE-600)1500497-1$$a10.1016/j.jneuroim.2017.12.001$$gVol. 314, p. 101 - 105$$p101 - 105$$tJournal of neuroimmunology$$v314$$x0165-5728$$y2018
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