TY  - JOUR
AU  - Bansi, Jens
AU  - Koliamitra, Christina
AU  - Bloch, Wilhelm
AU  - Joisten, Niklas
AU  - Schenk, Alexander
AU  - Watson, Matthew
AU  - Kool, Jan
AU  - Langdon, Dawn
AU  - Dalgas, Ulrik
AU  - Kesselring, Jürg
AU  - Zimmer, Philipp
TI  - Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training.
JO  - Journal of neuroimmunology
VL  - 314
SN  - 0165-5728
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2018-00225
SP  - 101 - 105
PY  - 2018
AB  - Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS. Further research is warranted to investigate whether these changes are associated with clinical measures (e.g. depressions and immune function).
LB  - PUB:(DE-HGF)16
C6  - pmid:29224960
DO  - DOI:10.1016/j.jneuroim.2017.12.001
UR  - https://inrepo02.dkfz.de/record/132547
ER  -