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@ARTICLE{Babaei:132624,
      author       = {M. Babaei$^*$ and L. Jansen and Y. Balavarca$^*$ and A.
                      Sjövall and A. Bos and T. van de Velde and M. Moreau and G.
                      Liberale and A. F. Gonçalves and M. J. Bento and C. M.
                      Ulrich$^*$ and P. Schrotz-King$^*$ and V. Lemmens and B.
                      Glimelius and H. Brenner$^*$},
      title        = {{N}eoadjuvant {T}herapy in {R}ectal {C}ancer {P}atients
                      {W}ith {C}linical {S}tage {II} to {III} {A}cross {E}uropean
                      {C}ountries: {V}ariations and {O}utcomes.},
      journal      = {Clinical colorectal cancer and other gastrointestinal
                      malignancies},
      volume       = {17},
      number       = {1},
      issn         = {1533-0028},
      address      = {Dallas, Tex.},
      publisher    = {Cancer Information Group},
      reportid     = {DKFZ-2018-00284},
      pages        = {e129-e142},
      year         = {2018},
      abstract     = {Neoadjuvant therapy improves survival of patients with
                      clinical stage II and III rectal cancer in clinical trials.
                      In this study, we investigated the administration of
                      neoadjuvant radiotherapy (neo-RT) and neoadjuvant
                      chemoradiotherapy (neo-CRT) and its association with
                      survival in resected patients in 2 European countries (The
                      Netherlands and Sweden) and at 3 specialist
                      centers.Administration of neoadjuvant treatment (all
                      registries) and overall survival after surgery in The
                      Netherlands and Sweden were assessed. Hazard ratios (HRs)
                      were obtained using Cox regression adjusted for potential
                      confounders.A total of 16,095 rectal cancer patients with
                      clinical stage II and III were eligible for analyses. Large
                      variations in administration of neo-RT and neo-CRT were
                      observed. Elderly patients less often received neo-RT and
                      neo-CRT. Patients with stage III disease received neo-CRT
                      more frequently than neo-RT. Administration of neo-RT versus
                      surgery without neoadjuvant treatment was significantly
                      associated with improved survival in The Netherlands (HR,
                      0.62; $95\%$ confidence interval [CI], 0.53-0.73) as well as
                      in Sweden (HR, 0.79; $95\%$ CI, 0.69-0.90). Administration
                      of neo-CRT was associated with enhanced survival in The
                      Netherlands (HR, 0.62; $95\%$ CI, 0.50-0.78) but not in
                      Sweden (HR, 0.97; $95\%$ CI, 0.80-1.18). The mortality of
                      patients treated with neo-CRT compared with neo-RT showed
                      inconsistent results in population-based centers.Our results
                      support an association of neo-RT with enhanced survival
                      among stage II and III rectal cancer patients. Comparing
                      neo-CRT with neo-RT, larger variations and inconsistent
                      results with respect to survival were observed across
                      centers.},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29074354},
      doi          = {10.1016/j.clcc.2017.09.002},
      url          = {https://inrepo02.dkfz.de/record/132624},
}