TY  - JOUR
AU  - Bendinger, Alina
AU  - Glowa, Christin
AU  - Peter, Jörg
AU  - Karger, Christian
TI  - Photoacoustic imaging to assess pixel-based sO2 distributions in experimental prostate tumors.
JO  - Journal of biomedical optics
VL  - 23
IS  - 3
SN  - 1083-3668
CY  - Bellingham, Wash.
PB  - SPIE
M1  - DKFZ-2018-00287
SP  - 1-11
PY  - 2018
AB  - A protocol for photoacoustic imaging (PAI) has been developed to assess pixel-based oxygen saturation (sO2) distributions of experimental tumor models. The protocol was applied to evaluate the dependence of PAI results on measurement settings, reproducibility of PAI, and for the characterization of the oxygenation status of experimental prostate tumor sublines (Dunning R3327-H, -HI, -AT1) implanted subcutaneously in male Copenhagen rats. The three-dimensional (3-D) PA data employing two wavelengths were used to estimate sO2 distributions. If the PA signal was sufficiently strong, the distributions were independent from signal gain, threshold, and positioning of animals. Reproducibility of sO2 distributions with respect to shape and median values was demonstrated over several days. The three tumor sublines were characterized by the shapes of their sO2 distributions and their temporal response after external changes of the oxygen supply (100
LB  - PUB:(DE-HGF)16
C6  - pmid:29560625
DO  - DOI:10.1117/1.JBO.23.3.036009
UR  - https://inrepo02.dkfz.de/record/132627
ER  -