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@ARTICLE{Block:132628,
      author       = {M. S. Block and R. A. Vierkant and P. F. Rambau and S. J.
                      Winham and P. Wagner and N. Traficante and A. Tołoczko and
                      D. G. Tiezzi and F. A. Taran and P. Sinn and W. Sieh and R.
                      Sharma and J. H. Rothstein and T. Ramón Y Cajal and L.
                      Paz-Ares and O. Oszurek and S. Orsulic and R. B. Ness and G.
                      Nelson and F. Modugno and J. Menkiszak and V. McGuire and B.
                      M. McCauley and M. Mack and J. Lubiński and T. A. Longacre
                      and Z. Li and J. Lester and C. J. Kennedy and K. R. Kalli
                      and A. Y. Jung$^*$ and S. E. Johnatty and M. Jimenez-Linan
                      and A. Jensen and M. P. Intermaggio and J. Hung and E.
                      Herpel and B. Y. Hernandez and A. D. Hartkopf and P. R.
                      Harnett and P. Ghatage and J. M. García-Bueno and B. Gao
                      and S. Fereday and U. Eilber$^*$ and R. P. Edwards and C. B.
                      de Sousa and J. M. de Andrade and A. Chudecka-Głaz and G.
                      Chenevix-Trench and A. Cazorla and S. Y. Brucker and J.
                      Alsop and A. S. Whittemore and H. Steed and A. Staebler and
                      K. B. Moysich and U. Menon and J. M. Koziak and S. Kommoss
                      and S. K. Kjaer and L. E. Kelemen and B. Y. Karlan and D. G.
                      Huntsman and E. Høgdall and J. Gronwald and M. T. Goodman
                      and B. Gilks and M. J. García and P. A. Fasching and A. de
                      Fazio and S. Deen and J. Chang-Claude$^*$ and F. J. Candido
                      Dos Reis and I. G. Campbell and J. D. Brenton and D. D.
                      Bowtell and J. Benítez and P. D. P. Pharoah and M. Köbel
                      and S. J. Ramus and E. L. Goode and D. Bowtell and G.
                      Chenevix-Trench and A. Green and P. Webb and A. DeFazio and
                      D. Gertig and N. Traficante and S. Fereday and S. Moore and
                      J. Hung and K. Harrap and T. Sadkowsky and N. Pandeya and M.
                      Malt and A. Mellon and R. Robertson and T. Vanden Bergh and
                      M. Jones and P. Mackenzie and J. Maidens and K. Nattress and
                      Y. E. Chiew and A. Stenlake and H. Sullivan and B. Alexander
                      and P. Ashover and S. Brown and T. Corrish and L. Green and
                      L. Jackman and K. Ferguson and K. Martin and A. Martyn and
                      B. Ranieri and J. White and V. Jayde and P. Mamers and L.
                      Bowes and L. Galletta and D. Giles and J. Hendley and K.
                      Alsop and T. Schmidt and H. Shirley and C. Ball and C. Young
                      and S. Viduka and H. Tran and S. Bilic and L. Glavinas and
                      J. Brooks and R. Stuart-Harris and F. Kirsten and J.
                      Rutovitz and P. Clingan and A. Glasgow and A. Proietto and
                      S. Braye and G. Otton and J. Shannon and T. Bonaventura and
                      J. Stewart and S. Begbie and M. Friedlander and D. Bell and
                      S. Baron-Hay and A. Ferrier and G. Gard and D. Nevell and N.
                      Pavlakis and S. Valmadre and B. Young and C. Camaris and R.
                      Crouch and L. Edwards and N. Hacker and D. Marsden and G.
                      Robertson and P. Beale and J. Beith and J. Carter and C.
                      Dalrymple and R. Houghton and P. Russell and M. Links and J.
                      Grygiel and J. Hill and A. Brand and K. Byth and R. Jaworski
                      and P. Harnett and R. Sharma and G. Wain and B. Ward and D.
                      Papadimos and A. Crandon and M. Cummings and K. Horwood and
                      A. Obermair and L. Perrin and D. Wyld and J. Nicklin and M.
                      Davy and M. K. Oehler and C. Hall and T. Dodd and T. Healy
                      and K. Pittman and D. Henderson and J. Miller and J. Pierdes
                      and P. Blomfield and D. Challis and R. McIntosh and A.
                      Parker and B. Brown and R. Rome and D. Allen and P. Grant
                      and S. Hyde and R. Laurie and M. Robbie and D. Healy and T.
                      Jobling and T. Manolitsas and J. McNealage and P. Rogers and
                      B. Susil and E. Sumithran and I. Simpson and K. Phillips and
                      D. Rischin and S. Fox and D. Johnson and S. Lade and M.
                      Loughrey and N. O'Callaghan and W. Murray and P. Waring and
                      V. Billson and J. Pyman and D. Neesham and M. Quinn and C.
                      Underhill and R. Bell and L. F. Ng and R. Blum and V. Ganju
                      and I. Hammond and Y. Leung and A. McCartney and M. Buck and
                      I. Haviv and D. Purdie and D. Whiteman and N. Zeps},
      collaboration = {A. O. C. S. Group},
      title        = {{M}y{D}88 and {TLR}4 {E}xpression in {E}pithelial {O}varian
                      {C}ancer.},
      journal      = {Mayo Clinic proceedings},
      volume       = {93},
      number       = {3},
      issn         = {0025-6196},
      address      = {Rochester, Minn.},
      publisher    = {Foundation},
      reportid     = {DKFZ-2018-00288},
      pages        = {307 - 320},
      year         = {2018},
      abstract     = {To evaluate myeloid differentiation primary response gene
                      88 (MyD88) and Toll-like receptor 4 (TLR4) expression in
                      relation to clinical features of epithelial ovarian cancer,
                      histologic subtypes, and overall survival.We conducted
                      centralized immunohistochemical staining, semi-quantitative
                      scoring, and survival analysis in 5263 patients
                      participating in the Ovarian Tumor Tissue Analysis
                      consortium. Patients were diagnosed between January 1, 1978,
                      and December 31, 2014, including 2865 high-grade serous
                      ovarian carcinomas (HGSOCs), with more than 12,000
                      person-years of follow-up time. Tissue microarrays were
                      stained for MyD88 and TLR4, and staining intensity was
                      classified using a 2-tiered system for each marker (weak vs
                      strong).Expression of MyD88 and TLR4 was similar in all
                      histotypes except clear cell ovarian cancer, which showed
                      reduced expression compared with other histotypes (P<.001
                      for both). In HGSOC, strong MyD88 expression was modestly
                      associated with shortened overall survival (hazard ratio
                      [HR], 1.13; $95\%$ CI, 1.01-1.26; P=.04) but was also
                      associated with advanced stage (P<.001). The expression of
                      TLR4 was not associated with survival. In low-grade serous
                      ovarian cancer (LGSOC), strong expression of both MyD88 and
                      TLR4 was associated with favorable survival (HR $[95\%$ CI],
                      0.49 [0.29-0.84] and 0.44 [0.21-0.89], respectively; P=.009
                      and P=.02, respectively).Results are consistent with an
                      association between strong MyD88 staining and advanced stage
                      and poorer survival in HGSOC and demonstrate correlation
                      between strong MyD88 and TLR4 staining and improved survival
                      in LGSOC, highlighting the biological differences between
                      the 2 serous histotypes.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29502561},
      pmc          = {pmc:PMC5870793},
      doi          = {10.1016/j.mayocp.2017.10.023},
      url          = {https://inrepo02.dkfz.de/record/132628},
}