% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hajek:132645,
      author       = {A. Hajek and J.-O. Bock and K.-U. Saum$^*$ and H.
                      Matschinger and H. Brenner$^*$ and B. Holleczek$^*$ and W.
                      E. Haefeli and D. Heider and H.-H. König},
      title        = {{F}railty and healthcare costs-longitudinal results of a
                      prospective cohort study.},
      journal      = {Age $\&$ ageing},
      volume       = {47},
      number       = {2},
      issn         = {1468-2834},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2018-00305},
      pages        = {233 - 241},
      year         = {2018},
      abstract     = {to investigate how frailty and frailty symptoms affect
                      healthcare costs in older age longitudinally.data were
                      gathered from a prospective cohort study in Saarland,
                      Germany (two waves with 3-year interval, n = 1,636 aged
                      57-84 years at baseline). Frailty was assessed by the five
                      Fried frailty criteria. Frailty was defined as having at
                      least three criteria, the presence of 1-2 criteria as
                      pre-frail. Healthcare costs were quantified based on
                      self-reported healthcare use in the sectors of inpatient
                      treatment, outpatient treatment, professional nursing care
                      and informal care as well as the provision of
                      pharmaceuticals, medical supplies and dental
                      prostheses.while the onset of pre-frailty did not increase
                      (log) total healthcare costs after adjusting for potential
                      confounders including comorbidity, progression from
                      non-frailty to frailty was associated with an increase in
                      total healthcare costs (for example, costs increased by ~54
                      and $101\%$ if 3 and 4 or 5 symptoms were present,
                      respectively). This association of frailty onset with
                      increased healthcare costs was in particular observed in the
                      inpatient sector and for informal nursing care. Among the
                      frailty symptoms, the onset of exhaustion was associated
                      with an increase in total healthcare costs, whereas changes
                      in slowness, weakness, weight loss and low-physical activity
                      were not significantly associated with an increase in total
                      healthcare costs.our data stress the economic relevance of
                      frailty in late life. Postponing or reducing frailty might
                      be fruitful in order to reduce healthcare costs.},
      cin          = {C070 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29036424},
      doi          = {10.1093/ageing/afx157},
      url          = {https://inrepo02.dkfz.de/record/132645},
}