% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{NyarangiDix:132664,
      author       = {J. N. Nyarangi-Dix and D. Tichy$^*$ and G. Hatiboglu and S.
                      Pahernik and G. Tosev and M. Hohenfellner},
      title        = {{C}omplete bladder neck preservation promotes long-term
                      post-prostatectomy continence without compromising midterm
                      oncological outcome: analysis of a randomised controlled
                      cohort.},
      journal      = {World journal of urology},
      volume       = {36},
      number       = {3},
      issn         = {1433-8726},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2018-00324},
      pages        = {349 - 355},
      year         = {2018},
      abstract     = {The only RCT available on complete bladder neck
                      preservation (cBNP) during radical prostatectomy reported
                      superior continence and QoL outcomes in the first 12 months
                      after cBNP. We provide the first data on long-term urinary
                      continence, QoL and biochemical recurrence (BCR) after
                      complete bladder neck preservation in a randomised
                      controlled cohort.After approval by IRB, 199 men recruited
                      for the randomised, controlled single-blind Heidelberger
                      cBNP Study had prostatectomy performed with (cBNP) or
                      without (noBNP) complete bladder neck preservation. Only men
                      with renewed consent for this follow-up were evaluated for
                      continence, QoL outcomes and BCR by ICIQ-SF self-assessment
                      questionnaire, Pad-use/day and PSA levels. Students-t test,
                      Pearson´s Chi-square, Fishers exact test and multiple
                      logistic regression analyses were applied.Mean follow-up was
                      approx. 4 years. There were no significant differences in
                      baseline characteristics between responders/non-responders
                      or between study groups. We noted significantly higher
                      continence rates (p = 0.004), less pad-use (p < 0.001),
                      reduced frequency (p = 0.023) and amount (p = 0.009) of
                      urine loss, and higher QoL outcomes (p = 0.012) after
                      cBNP. A younger age positively influenced continence
                      (OR = 0.91), but the multivariate analysis found cBNP to
                      be the only independent predictor of continence
                      (p = 0.008; OR = 8.1). pT stage was the only predictor
                      for positive surgical margins (PSM; p < 0.001). There was
                      no significant difference in pT stage (p = 0.23) or BCR
                      (p = 0.63) between study groups and also no significant
                      correlation between BCR and presence (p = 0.26) or
                      localisation (p = 0.11) of PSM, nerve sparing
                      (p = 0.70), surgeon (p = 0.41), preoperative PSA
                      (p = 0.53) or pT stage (p = 0.17). No cancer-related
                      death was noted.Results of this first follow-up on a
                      prospective randomised controlled cohort demonstrate that
                      cBNP is associated with significantly higher continence and
                      QoL outcomes without compromising cancer control making cBNP
                      a novel objective during radical prostatectomy.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29214353},
      doi          = {10.1007/s00345-017-2134-1},
      url          = {https://inrepo02.dkfz.de/record/132664},
}