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@ARTICLE{vanVulpen:132679,
      author       = {J. K. van Vulpen and M. Schmidt$^*$ and M. J. Velthuis and
                      J. Wiskemann and A. Schneeweiss and R. C. H. Vermeulen and
                      N. Habermann and C. M. Ulrich and P. H. M. Peeters and E.
                      van der Wall and A. M. May and K. Steindorf$^*$},
      title        = {{E}ffects of physical exercise on markers of inflammation
                      in breast cancer patients during adjuvant chemotherapy.},
      journal      = {Breast cancer research and treatment},
      volume       = {168},
      number       = {2},
      issn         = {1573-7217},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2018-00339},
      pages        = {421 - 431},
      year         = {2018},
      note         = {van Vulpen JK*, Schmidt ME* (First Authors) * shared
                      positionsMay AM*, Steindorf K* (Last Authors) * shared
                      positionsshared positions},
      abstract     = {Exercise has been shown to reduce fatigue during cancer
                      treatment. Hypothesized mechanisms include inflammatory
                      pathways. Therefore, we investigated effects of exercise on
                      markers of inflammation in breast cancer patients during
                      adjuvant chemotherapy.We pooled data from two randomized
                      controlled exercise intervention trials with breast cancer
                      patients during adjuvant chemotherapy (n = 130), which had
                      previously shown beneficial effects of exercise on fatigue.
                      Exercise comprised a 12-week resistance training (BEATE
                      study) or an 18-week combined resistance and aerobic
                      training (PACT study). Serum IL-6, IL-1ra, and the
                      IL-6/IL-1ra ratio were quantified at baseline,
                      mid-intervention, post-intervention, and 6-9 months
                      post-baseline.Mixed effect models showed significant
                      increases in IL-6 and IL-6/IL-1ra ratio during chemotherapy
                      and decreases afterwards. Differences between exercise and
                      control group were not significant at any time point.
                      Changes in total cancer-related fatigue were significantly
                      correlated with changes in IL-6/IL-1ra ratio (partial
                      correlation r = 0.23) and IL-6 (r = 0.21), and changes
                      in physical cancer-related fatigue with changes in
                      IL-6/IL-1ra ratio (r = 0.21).Changes in fatigue were
                      slightly correlated with changes in inflammatory markers,
                      and there was a strong inflammatory response to adjuvant
                      chemotherapy. The supervised exercise training did not
                      counteract this increase in inflammation, suggesting that
                      beneficial effects of exercise on fatigue during adjuvant
                      chemotherapy for breast cancer are not essentially mediated
                      by IL-6, IL-1ra, or the IL-6/IL-1ra ratio.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29235043},
      doi          = {10.1007/s10549-017-4608-7},
      url          = {https://inrepo02.dkfz.de/record/132679},
}