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@ARTICLE{Capper:132685,
      author       = {D. Capper$^*$ and D. Jones$^*$ and M. Sill$^*$ and V.
                      Hovestadt$^*$ and D. Schrimpf$^*$ and D. Sturm$^*$ and C.
                      Koelsche$^*$ and F. Sahm$^*$ and L. Chavez$^*$ and D. E.
                      Reuss$^*$ and A. Kratz$^*$ and A. K. Wefers$^*$ and K.
                      Huang$^*$ and K. Pajtler$^*$ and L. Schweizer and D.
                      Stichel$^*$ and A. Olar and N. W. Engel and K.
                      Lindenberg$^*$ and P. Harter$^*$ and A. K. Braczynski$^*$
                      and K. H. Plate$^*$ and H. Dohmen and B. K. Garvalov and R.
                      Coras and A. Hölsken and E. Hewer and M.
                      Bewerunge-Hudler$^*$ and M. Schick$^*$ and R. Fischer$^*$
                      and R. Beschorner and J. Schittenhelm and O. Staszewski and
                      K. Wani and P. Varlet and M. Pages and P. Temming and D.
                      Lohmann and F. Selt$^*$ and H. Witt$^*$ and T. Milde$^*$ and
                      O. Witt$^*$ and E. Aronica and F. Giangaspero and E. Rushing
                      and W. Scheurlen and C. Geisenberger and F. J. Rodriguez and
                      A. Becker and M. Preusser and C. Haberler and R. Bjerkvig
                      and J. Cryan and M. Farrell and M. Deckert and J. Hench and
                      S. Frank and J. Serrano and K. Kannan and A. Tsirigos and W.
                      Brück and S. Hofer and S. Brehmer and M. Seiz-Rosenhagen
                      and D. Hänggi and V. Hans and S. Rozsnoki and J. R.
                      Hansford and P. Kohlhof and B. W. Kristensen and M. Lechner
                      and B. Lopes and C. Mawrin and R. Ketter and A. Kulozik and
                      Z. Khatib and F. Heppner and A. Koch and A. Jouvet and C.
                      Keohane and H. Mühleisen and W. Mueller and U. Pohl and M.
                      Prinz and A. Benner$^*$ and M. Zapatka$^*$ and N. G.
                      Gottardo and P. H. Driever and C. M. Kramm and H. L. Müller
                      and S. Rutkowski and K. von Hoff and M. C. Frühwald and A.
                      Gnekow and G. Fleischhack and S. Tippelt and G. Calaminus
                      and C.-M. Monoranu and A. Perry and C. Jones and T. S.
                      Jacques and B. Radlwimmer$^*$ and M. Gessi and T. Pietsch
                      and J. Schramm and G. Schackert and M. Westphal and G.
                      Reifenberger$^*$ and P. Wesseling and M. Weller and V. P.
                      Collins and I. Blümcke and M. Bendszus and J. Debus and A.
                      Huang and N. Jabado and P. A. Northcott and W. Paulus and A.
                      Gajjar and G. W. Robinson and M. D. Taylor and Z.
                      Jaunmuktane and M. Ryzhova and M. Platten and A. Unterberg
                      and W. Wick and M. A. Karajannis and M. Mittelbronn$^*$ and
                      T. Acker and C. Hartmann and K. Aldape and U. Schüller and
                      R. Buslei and P. Lichter$^*$ and M. Kool$^*$ and C.
                      Herold-Mende and D. W. Ellison and M. Hasselblatt and M.
                      Snuderl and S. Brandner and A. Korshunov$^*$ and A. von
                      Deimling$^*$ and S. Pfister$^*$},
      title        = {{DNA} methylation-based classification of central nervous
                      system tumours.},
      journal      = {Nature},
      volume       = {555},
      number       = {7697},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2018-00343},
      pages        = {469 - 474},
      year         = {2018},
      abstract     = {Accurate pathological diagnosis is crucial for optimal
                      management of patients with cancer. For the approximately
                      100 known tumour types of the central nervous system,
                      standardization of the diagnostic process has been shown to
                      be particularly challenging-with substantial inter-observer
                      variability in the histopathological diagnosis of many
                      tumour types. Here we present a comprehensive approach for
                      the DNA methylation-based classification of central nervous
                      system tumours across all entities and age groups, and
                      demonstrate its application in a routine diagnostic setting.
                      We show that the availability of this method may have a
                      substantial impact on diagnostic precision compared to
                      standard methods, resulting in a change of diagnosis in up
                      to $12\%$ of prospective cases. For broader accessibility,
                      we have designed a free online classifier tool, the use of
                      which does not require any additional onsite data
                      processing. Our results provide a blueprint for the
                      generation of machine-learning-based tumour classifiers
                      across other cancer entities, with the potential to
                      fundamentally transform tumour pathology.},
      cin          = {G380 / L101 / L201 / B062 / C060 / B060 / L501 / W110 /
                      G340 / L401},
      ddc          = {070},
      cid          = {I:(DE-He78)G380-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)L201-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)L501-20160331 / I:(DE-He78)W110-20160331 /
                      I:(DE-He78)G340-20160331 / I:(DE-He78)L401-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29539639},
      doi          = {10.1038/nature26000},
      url          = {https://inrepo02.dkfz.de/record/132685},
}