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@ARTICLE{Bogs:132693,
      author       = {T. Bogs and N. Zwink$^*$ and V. Chonitzki and A. Hölscher
                      and T. M. Boemers and O. Münsterer and R. Kurz and A.
                      Heydweiller and M. Pauly and A. Leutner and B. M. Ure and M.
                      Lacher and O. J. Deffaa and H. Thiele and S. Bagci and E.
                      Jenetzky$^*$ and J. Schumacher and H. Reutter},
      title        = {{E}sophageal {A}tresia with or without {T}racheoesophageal
                      {F}istula ({EA}/{TEF}): {A}ssociation of {D}ifferent
                      {EA}/{TEF} {S}ubtypes with {S}pecific {C}o-occurring
                      {C}ongenital {A}nomalies and {I}mplications for {D}iagnostic
                      {W}orkup.},
      journal      = {European journal of pediatric surgery},
      volume       = {28},
      number       = {2},
      issn         = {1439-359X},
      address      = {Stuttgart},
      publisher    = {Thieme},
      reportid     = {DKFZ-2018-00350},
      pages        = {176 - 182},
      year         = {2018},
      abstract     = {Esophageal atresia with or without tracheoesophageal
                      fistula (EA/TEF) represents the most common developmental
                      malformation of the upper digestive tract. It is classified
                      into six subtypes according to the classification of Vogt,
                      depending on anatomical variation of this malformation.
                      Around $50\%$ of the patients with EA/TEF present additional
                      anomalies, which often influence, next to the EA/TEF
                      subtype, the overall prognosis of EA/TEF newborns. Here, we
                      investigated the association of the different EA/TEF
                      subtypes with co-occurring congenital anomalies in EA/TEF
                      patients and demonstrate their implications for postnatal
                      diagnostic workup. We investigated 333 patients of a large
                      German multicenter study born between 1980 and 2012. After
                      evaluation of all available clinical records, 235 patients
                      were included in our analysis. We compared our results with
                      existing data. The highest risk for co-occurring anomalies
                      was seen in patients with most common Vogt 3b
                      (p = 0.024), especially for additional gastrointestinal
                      anomalies (p = 0.04). Co-occurring anomalies of the skin
                      were significantly more common in patients with subtype Vogt
                      2 (p = 0.024). A significant correlation was observed
                      for an impaired neurodevelopmental outcome and EA/TEF Vogt
                      3a (p = 0.041). Patients with EA/TEF showed a higher
                      risk to present with any additional congenital anomaly
                      compared with the general population (p < 0.001). Our
                      results warrant thorough clinical workup for
                      gastrointestinal anomalies especially in patients with Vogt
                      3b. Moreover, it might be necessary to focus on a thorough
                      aftercare for neurocognitive development in patients with
                      Vogt 3a. The here presented observations need to be
                      confirmed by future studies.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28061520},
      doi          = {10.1055/s-0036-1597946},
      url          = {https://inrepo02.dkfz.de/record/132693},
}