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@ARTICLE{Bchele:132695,
      author       = {G. Büchele and K. P. Günther and H. Brenner$^*$ and W.
                      Puhl and T. Stürmer and D. Rothenbacher and R. E. Brenner},
      title        = {{O}steoarthritis-patterns, cardio-metabolic risk factors
                      and risk of all-cause mortality: 20 years follow-up in
                      patients after hip or knee replacement.},
      journal      = {Scientific reports},
      volume       = {8},
      number       = {1},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2018-00352},
      pages        = {5253},
      year         = {2018},
      abstract     = {Osteoarthritis (OA) is a common musculoskeletal disorder
                      and occur in different patterns. However, its impact on
                      long-term all-cause-mortality is inconclusive.Investigate
                      20-year all-cause-mortality in patients with hip/knee
                      arthroplasty (recruited 1995/1996, N = 809) from the Ulm
                      Osteoarthritis Study-cohort, in comparison to general
                      population. Furthermore, to enlighten the triangle between
                      baseline life-style and cardio-metabolic risk factors,
                      phenotypic OA-patterns (laterality, generalization, cause)
                      and all-cause-mortality. Mortality was assessed during 20
                      years follow-up. Standardized mortality ratios (SMR),
                      adjusted odds ratios and hazard ratios (aHR) were
                      calculated. After five years cohort-mortality was reduced
                      compared to the general population, however 20 years later
                      assimilated (SMR = 1.11; $95\%-CI$ 0.73-1.49).
                      OA-patterns were associated with age, cholesterol, and
                      overweight/obesity. In comparison to primary OA decreased
                      mortality was observed for patients with secondary OA
                      (aHR = 0.76; $95\%-CI$ 0.61-0.95) adjusted for age,
                      smoking, overweight/obesity, diabetes, hypertension, cardiac
                      insufficiency, uric acid, and lower cholesterol. There was
                      no increased mortality in patients after 20 years follow-up
                      compared to general population. Significantly decreased
                      mortality in secondary compared to primary OA suggests a
                      subtype-specific involvement of systemic co-factors in
                      determination of all-cause-mortality. Because
                      cardio-metabolic risk factors were associated with increased
                      risk of bilateral OA and lower long-term survival, those
                      risk factors should be consequently targeted in
                      OA-patients.},
      cin          = {C070 / G110},
      ddc          = {000},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29588472},
      pmc          = {pmc:PMC5869736},
      doi          = {10.1038/s41598-018-23573-2},
      url          = {https://inrepo02.dkfz.de/record/132695},
}