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| Home > Publications database > Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement. > print |
| Home > Publications database > Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement. > print |
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| 100 | 1 | _ | |a Büchele, G. |b 0 |
| 245 | _ | _ | |a Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement. |
| 260 | _ | _ | |a London |c 2018 |b Nature Publishing Group |
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| 520 | _ | _ | |a Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive.Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality. Mortality was assessed during 20 years follow-up. Standardized mortality ratios (SMR), adjusted odds ratios and hazard ratios (aHR) were calculated. After five years cohort-mortality was reduced compared to the general population, however 20 years later assimilated (SMR = 1.11; 95%-CI 0.73-1.49). OA-patterns were associated with age, cholesterol, and overweight/obesity. In comparison to primary OA decreased mortality was observed for patients with secondary OA (aHR = 0.76; 95%-CI 0.61-0.95) adjusted for age, smoking, overweight/obesity, diabetes, hypertension, cardiac insufficiency, uric acid, and lower cholesterol. There was no increased mortality in patients after 20 years follow-up compared to general population. Significantly decreased mortality in secondary compared to primary OA suggests a subtype-specific involvement of systemic co-factors in determination of all-cause-mortality. Because cardio-metabolic risk factors were associated with increased risk of bilateral OA and lower long-term survival, those risk factors should be consequently targeted in OA-patients. |
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| 700 | 1 | _ | |a Günther, K. P. |b 1 |
| 700 | 1 | _ | |a Brenner, H. |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 2 |u dkfz |
| 700 | 1 | _ | |a Puhl, W. |b 3 |
| 700 | 1 | _ | |a Stürmer, T. |b 4 |
| 700 | 1 | _ | |a Rothenbacher, D. |b 5 |
| 700 | 1 | _ | |a Brenner, R. E. |b 6 |
| 773 | _ | _ | |a 10.1038/s41598-018-23573-2 |g Vol. 8, no. 1, p. 5253 |0 PERI:(DE-600)2615211-3 |n 1 |p 5253 |t Scientific reports |v 8 |y 2018 |x 2045-2322 |
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