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@ARTICLE{Filbin:132712,
      author       = {M. G. Filbin and D. Sturm$^*$},
      title        = {{G}liomas in {C}hildren.},
      journal      = {Seminars in neurology},
      volume       = {38},
      number       = {1},
      issn         = {1098-9021},
      address      = {New York, NY},
      publisher    = {Thieme Medical Publ.},
      reportid     = {DKFZ-2018-00366},
      pages        = {121 - 130},
      year         = {2018},
      abstract     = {Gliomas are the most common primary central nervous system
                      (CNS) neoplasms in children and adolescents and are thought
                      to arise from their glial progenitors or stem cells.
                      Although the exact cells of origin for most pediatric
                      gliomas remain to be identified, our current understanding
                      is that specific cell populations during CNS development are
                      susceptible to particular oncogenic events during certain
                      time windows and thus give rise to pediatric gliomas with
                      distinct histological, molecular, and clinical features.
                      These may be roughly segregated into low-grade gliomas (WHO
                      grades I or II; including most mixed glial-neuronal tumors)
                      and high-grade gliomas (WHO grades III or IV) according to
                      their clinical course when untreated, even though this is
                      not yet entirely clear for some of the recently emerging
                      groups. The genetic and epigenetic characterization of
                      pediatric gliomas across ages and histologies has
                      facilitated the delineation of biologically relevant
                      subgroups and have revealed potentially targetable
                      alterations in some of them. This review outlines diagnostic
                      features and molecular alterations in pediatric low- and
                      high-grade gliomas and how the latter might be exploited
                      with future targeted therapeutic strategies.},
      subtyp        = {Review Article},
      cin          = {B062 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29548059},
      doi          = {10.1055/s-0038-1635106},
      url          = {https://inrepo02.dkfz.de/record/132712},
}