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@ARTICLE{Gerstner:132713,
      author       = {E. R. Gerstner and K. Pajtler$^*$},
      title        = {{E}pendymoma.},
      journal      = {Seminars in neurology},
      volume       = {38},
      number       = {1},
      issn         = {1098-9021},
      address      = {New York, NY},
      publisher    = {Thieme Medical Publ.},
      reportid     = {DKFZ-2018-00367},
      pages        = {104 - 111},
      year         = {2018},
      abstract     = {Ependymoma can arise throughout the whole neuraxis. In
                      children, tumors predominantly occur intracranially, whereas
                      the spine is the most prevalent location in adults.
                      Significant variance in the grade II versus grade III
                      distinction of ependymomas has led to the acknowledgment
                      that the clinical utility of histopathological
                      classification is limited. Epigenomic profiling efforts have
                      identified molecularly distinct groups of ependymomas that
                      adequately reflect the biological, clinical, and
                      histopathological heterogeneities across anatomical
                      compartments, age groups, and grades. The recent update of
                      the World Health Organization classification of central
                      nervous system tumors has already integrated one of these
                      groups, and molecular classification will be part of future
                      clinical trials to improve risk stratification. Clinical
                      management of this rare disease is challenging, making
                      professional experience and intensified multidisciplinary
                      cooperation pivotal factors for treatment success. Novel
                      research strategies are currently applied for target
                      discovery in ependymomas since for most molecular groups,
                      genetic drivers are unknown.},
      subtyp        = {Review Article},
      cin          = {B062 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29548057},
      doi          = {10.1055/s-0038-1636503},
      url          = {https://inrepo02.dkfz.de/record/132713},
}