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000132715 0247_ $$2doi$$a10.1038/nature25480
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000132715 0247_ $$2ISSN$$a1476-4687
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000132715 1001_ $$0P:(DE-He78)932918ed0e8d8790a81235528019a8e0$$aGröbner, Susanne$$b0$$eFirst author
000132715 245__ $$aThe landscape of genomic alterations across childhood cancers.
000132715 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2018
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000132715 520__ $$aPan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7-8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.
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000132715 7001_ $$aWeischenfeldt, Joachim$$b2
000132715 7001_ $$0P:(DE-He78)e84b3187ddd3529f884082e30f228c66$$aBuchhalter, Ivo$$b3
000132715 7001_ $$0P:(DE-He78)e053817bc90becc8a8dd8250e677e773$$aKleinheinz, Kortine$$b4
000132715 7001_ $$aRudneva, Vasilisa A$$b5
000132715 7001_ $$0P:(DE-He78)3fdc3623477264cb5d0e14f256dbfbb8$$aJohann, Pascal$$b6
000132715 7001_ $$aBalasubramanian, Gnana Prakash$$b7
000132715 7001_ $$aSegura-Wang, Maia$$b8
000132715 7001_ $$0P:(DE-He78)b0b3740107f746e09dc23fdf25eb0629$$aBrabetz, Sebastian$$b9
000132715 7001_ $$aBender, Sebastian$$b10
000132715 7001_ $$0P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aHutter, Barbara$$b11
000132715 7001_ $$0P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807$$aSturm, Dominik$$b12
000132715 7001_ $$0P:(DE-He78)c0538fae462bd98e3cd8d54ed885b0eb$$aPfaff, Elke$$b13
000132715 7001_ $$0P:(DE-He78)a5218e4871866cd5ab2312e594ca403d$$aHübschmann, Daniel$$b14$$udkfz
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000132715 7001_ $$0P:(DE-He78)ae1b30b052ea4c3ea118a5ca3b46adc3$$aHeinold, Michael$$b16
000132715 7001_ $$0P:(DE-He78)442f4a5d2d41f01896229fac4d339d45$$aEils, Jürgen$$b17
000132715 7001_ $$0P:(DE-He78)5398550c21bc4ce3b0ff670b04150334$$aLawerenz, Christian$$b18
000132715 7001_ $$0P:(DE-He78)df8660bc5aba525f7fb6dba4aac15c1c$$aErkek, Serap$$b19
000132715 7001_ $$0P:(DE-He78)b84967c4f073b71405404f3719c788cd$$aLambo, Sander$$b20
000132715 7001_ $$aWaszak, Sebastian$$b21
000132715 7001_ $$aBlattmann, Claudia$$b22
000132715 7001_ $$aBorkhardt, Arndt$$b23
000132715 7001_ $$aKuhlen, Michaela$$b24
000132715 7001_ $$aEggert, Angelika$$b25
000132715 7001_ $$aFulda, Simone$$b26
000132715 7001_ $$aGessler, Manfred$$b27
000132715 7001_ $$aWegert, Jenny$$b28
000132715 7001_ $$aKappler, Roland$$b29
000132715 7001_ $$aBaumhoer, Daniel$$b30
000132715 7001_ $$aBurdach, Stefan$$b31
000132715 7001_ $$aKirschner-Schwabe, Renate$$b32
000132715 7001_ $$aKontny, Udo$$b33
000132715 7001_ $$aKulozik, Andreas E$$b34
000132715 7001_ $$aLohmann, Dietmar$$b35
000132715 7001_ $$aHettmer, Simone$$b36
000132715 7001_ $$aEckert, Cornelia$$b37
000132715 7001_ $$aBielack, Stefan$$b38
000132715 7001_ $$aNathrath, Michaela$$b39
000132715 7001_ $$aNiemeyer, Charlotte$$b40
000132715 7001_ $$aRichter, Günther H$$b41
000132715 7001_ $$0P:(DE-He78)91317a47fc8532e3daf0d0b362c2a27e$$aSchulte, Johannes$$b42
000132715 7001_ $$aSiebert, Reiner$$b43
000132715 7001_ $$0P:(DE-He78)91f32735ee876c579d63c05a7f4778dd$$aWestermann, Frank$$b44
000132715 7001_ $$aMolenaar, Jan J$$b45
000132715 7001_ $$aVassal, Gilles$$b46
000132715 7001_ $$0P:(DE-He78)046fd145f1008f83f6236580727bbc0f$$aWitt, Hendrik$$b47
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000132715 7001_ $$aBurkhardt, Birgit$$b50
000132715 7001_ $$aKratz, Christian P$$b51
000132715 7001_ $$0P:(DE-He78)143af26de9d57bf624771616318aaf7c$$aWitt, Olaf$$b52
000132715 7001_ $$avan Tilburg, Cornelis M$$b53
000132715 7001_ $$aKramm, Christof M$$b54
000132715 7001_ $$aFleischhack, Gudrun$$b55
000132715 7001_ $$aDirksen, Uta$$b56
000132715 7001_ $$aRutkowski, Stefan$$b57
000132715 7001_ $$aFrühwald, Michael$$b58
000132715 7001_ $$avon Hoff, Katja$$b59
000132715 7001_ $$0P:(DE-He78)1efb774993effe7a66a6ffc1b1cf9ccb$$aWolf, Stephan$$b60
000132715 7001_ $$aKlingebiel, Thomas$$b61
000132715 7001_ $$aKoscielniak, Ewa$$b62
000132715 7001_ $$aLandgraf, Pablo$$b63
000132715 7001_ $$aKoster, Jan$$b64
000132715 7001_ $$aResnick, Adam C$$b65
000132715 7001_ $$aZhang, Jinghui$$b66
000132715 7001_ $$aLiu, Yanling$$b67
000132715 7001_ $$aZhou, Xin$$b68
000132715 7001_ $$aWaanders, Angela J$$b69
000132715 7001_ $$aZwijnenburg, Danny A$$b70
000132715 7001_ $$aRaman, Pichai$$b71
000132715 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b72
000132715 7001_ $$0P:(DE-He78)4fbd3823a23414f37b9f1a445cad566e$$aWeber, Ursula$$b73
000132715 7001_ $$aNorthcott, Paul A$$b74
000132715 7001_ $$0P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d$$aPajtler, Kristian$$b75
000132715 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b76
000132715 7001_ $$aPiro, Rosario M$$b77
000132715 7001_ $$aKorbel, Jan O$$b78
000132715 7001_ $$0P:(DE-He78)f2a782242acf94a3114d75c45dc75b37$$aSchlesner, Matthias$$b79
000132715 7001_ $$0P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0$$aEils, Roland$$b80
000132715 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b81
000132715 7001_ $$0P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c$$aLichter, Peter$$b82
000132715 7001_ $$0P:(DE-He78)082dd3179733e3e716a58eb90f418a78$$aChavez, Lukas$$b83$$eLast author
000132715 7001_ $$0P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7$$aZapatka, Marc$$b84$$eLast author
000132715 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b85$$eLast author
000132715 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/nature25480$$gVol. 555, no. 7696, p. 321 - 327$$n7696$$p321 - 327$$tNature <London>$$v555$$x1476-4687$$y2018
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