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@ARTICLE{Grbner:132715,
      author       = {S. Gröbner$^*$ and B. Worst$^*$ and J. Weischenfeldt and
                      I. Buchhalter$^*$ and K. Kleinheinz$^*$ and V. A. Rudneva
                      and P. Johann$^*$ and G. P. Balasubramanian and M.
                      Segura-Wang and S. Brabetz$^*$ and S. Bender and B.
                      Hutter$^*$ and D. Sturm$^*$ and E. Pfaff$^*$ and D.
                      Hübschmann$^*$ and G. Zipprich$^*$ and M. Heinold$^*$ and
                      J. Eils$^*$ and C. Lawerenz$^*$ and S. Erkek$^*$ and S.
                      Lambo$^*$ and S. Waszak and C. Blattmann and A. Borkhardt
                      and M. Kuhlen and A. Eggert and S. Fulda and M. Gessler and
                      J. Wegert and R. Kappler and D. Baumhoer and S. Burdach and
                      R. Kirschner-Schwabe and U. Kontny and A. E. Kulozik and D.
                      Lohmann and S. Hettmer and C. Eckert and S. Bielack and M.
                      Nathrath and C. Niemeyer and G. H. Richter and J.
                      Schulte$^*$ and R. Siebert and F. Westermann$^*$ and J. J.
                      Molenaar and G. Vassal and H. Witt$^*$ and B. Burkhardt and
                      C. P. Kratz and O. Witt$^*$ and C. M. van Tilburg and C. M.
                      Kramm and G. Fleischhack and U. Dirksen and S. Rutkowski and
                      M. Frühwald and K. von Hoff and S. Wolf$^*$ and T.
                      Klingebiel and E. Koscielniak and P. Landgraf and J. Koster
                      and A. C. Resnick and J. Zhang and Y. Liu and X. Zhou and A.
                      J. Waanders and D. A. Zwijnenburg and P. Raman and B.
                      Brors$^*$ and U. Weber$^*$ and P. A. Northcott and K.
                      Pajtler$^*$ and M. Kool$^*$ and R. M. Piro and J. O. Korbel
                      and M. Schlesner$^*$ and R. Eils$^*$ and D. Jones$^*$ and P.
                      Lichter$^*$ and L. Chavez$^*$ and M. Zapatka$^*$ and S.
                      Pfister$^*$},
      collaboration = {I. P. Project and I. M. Project},
      title        = {{T}he landscape of genomic alterations across childhood
                      cancers.},
      journal      = {Nature},
      volume       = {555},
      number       = {7696},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2018-00369},
      pages        = {321 - 327},
      year         = {2018},
      abstract     = {Pan-cancer analyses that examine commonalities and
                      differences among various cancer types have emerged as a
                      powerful way to obtain novel insights into cancer biology.
                      Here we present a comprehensive analysis of genetic
                      alterations in a pan-cancer cohort including 961 tumours
                      from children, adolescents, and young adults, comprising 24
                      distinct molecular types of cancer. Using a standardized
                      workflow, we identified marked differences in terms of
                      mutation frequency and significantly mutated genes in
                      comparison to previously analysed adult cancers. Genetic
                      alterations in 149 putative cancer driver genes separate the
                      tumours into two classes: small mutation and
                      structural/copy-number variant (correlating with germline
                      variants). Structural variants, hyperdiploidy, and
                      chromothripsis are linked to TP53 mutation status and
                      mutational signatures. Our data suggest that $7-8\%$ of the
                      children in this cohort carry an unambiguous predisposing
                      germline variant and that nearly $50\%$ of paediatric
                      neoplasms harbour a potentially druggable event, which is
                      highly relevant for the design of future clinical trials.},
      cin          = {B062 / L101 / B080 / G200 / B087 / G340 / W190 / B060 /
                      B240},
      ddc          = {070},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)B080-20160331 / I:(DE-He78)G200-20160331 /
                      I:(DE-He78)B087-20160331 / I:(DE-He78)G340-20160331 /
                      I:(DE-He78)W190-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)B240-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29489754},
      doi          = {10.1038/nature25480},
      url          = {https://inrepo02.dkfz.de/record/132715},
}