%0 Journal Article
%A Piechotta, Paula L
%A Bonekamp, David
%A Sill, Martin
%A Wick, Antje
%A Wick, Wolfgang
%A Bendszus, Martin
%A Kickingereder, Philipp
%T Increased Delay Between Gadolinium Chelate Administration and T1-Weighted Magnetic Resonance Imaging Acquisition Increases Contrast-Enhancing Tumor Volumes and T1 Intensities in Brain Tumor Patients.
%J Investigative radiology
%V 53
%N 4
%@ 0020-9996
%C Philadelphia, Pa.
%I Lippincott Williams & Wilkins
%M DKFZ-2018-00381
%P 223 - 228
%D 2018
%X The aim of this study was to evaluate the impact of delayed T1-weighted (T1-w) MRI acquisition after gadolinium chelate administration on brain tumor volumes and T1-w intensities.Fifty-five patients with histologically confirmed, contrast-enhancing intra-axial brain tumors were analyzed in this prospective test-retest study. Patients underwent 2 consecutive 3 T MRI scans (separated by a 1-minute break) during routine follow-up with contrast-enhanced T1 (ceT1-w), T2, and FLAIR acquisition. Macrocyclic gadolinium chelate-based contrast agent was only administered before the first ceT1-w acquisition; median latency to ceT1-w acquisition was 6.72 minutes (IQR, 6.53-6.92) in the first and 16.27 minutes (IQR, 15.49-17.26) in the second scan. Changes in tumor volumes and relative ceT1-w intensities between the 2 acquisitions were quantitatively assessed following semiautomated tumor segmentation (separately for contrast-enhancement [CE], necrosis [NEC], and nonenhancing [NE] tumor).Semiautomatically segmented CE tumor volumes were significantly larger in the second acquisition (median +32
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29200014
%R 10.1097/RLI.0000000000000432
%U https://inrepo02.dkfz.de/record/132727