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@ARTICLE{Opstelten:132748,
      author       = {J. L. Opstelten and S. S. M. Chan and A. R. Hart and F. D.
                      M. van Schaik and P. D. Siersema and E. G. W. M. Lentjes and
                      K.-T. Khaw and R. Luben and T. J. Key and H. Boeing and M.
                      M. Bergmann and K. Overvad and D. Palli and G. Masala and A.
                      Racine and F. Carbonnel and M.-C. Boutron-Ruault and A.
                      Tjønneland and A. Olsen and V. Andersen and R. Kaaks$^*$
                      and T. Kühn$^*$ and R. Tumino and A. Trichopoulou and P. H.
                      M. Peeters and W. M. M. Verschuren and B. J. M. Witteman and
                      B. Oldenburg},
      title        = {{P}rediagnostic {S}erum {V}itamin {D} {L}evels and the
                      {R}isk of {C}rohn's {D}isease and {U}lcerative {C}olitis in
                      {E}uropean {P}opulations: {A} {N}ested {C}ase-{C}ontrol
                      {S}tudy.},
      journal      = {Inflammatory bowel diseases},
      volume       = {24},
      number       = {3},
      issn         = {1536-4844},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {DKFZ-2018-00401},
      pages        = {633 - 640},
      year         = {2018},
      abstract     = {A low vitamin D status has been put forward as a potential
                      risk factor for the development of inflammatory bowel
                      disease (IBD). This study investigated the association
                      between prediagnostic circulating vitamin D concentrations
                      and dietary intakes of vitamin D, and the risk of Crohn's
                      disease (CD) and ulcerative colitis (UC).Among 359,728
                      participants of the European Prospective Investigation into
                      Cancer and Nutrition cohort, individuals who developed CD or
                      UC after enrollment were identified. Each case was matched
                      with2 controls by center, gender, age, date of recruitment,
                      and follow-up time. At cohort entry, blood samples were
                      collected and dietary vitamin D intakes were obtained from
                      validated food frequency questionnaires. Serum
                      25-hydroxyvitamin D levels were measured using liquid
                      chromatography-tandem mass spectrometry. Conditional
                      logistic regression was performed to determine the odds of
                      CD and UC.Seventy-two participants developed CD and 169
                      participants developed UC after a median follow-up of 4.7
                      and 4.1 years, respectively. Compared with the lowest
                      quartile, no associations with the 3 higher quartiles of
                      vitamin D concentrations were observed for CD (p trend =
                      0.34) or UC (p trend = 0.66). Similarly, no associations
                      were detected when serum vitamin D levels were analyzed as a
                      continuous variable. Dietary vitamin D intakes were not
                      associated with CD (p trend = 0.39) or UC (p trend =
                      0.83).Vitamin D status was not associated with the
                      development of CD or UC. This does not suggest a major role
                      for vitamin D deficiency in the etiology of IBD, although
                      larger studies are needed to confirm these findings.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29462382},
      doi          = {10.1093/ibd/izx050},
      url          = {https://inrepo02.dkfz.de/record/132748},
}