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@ARTICLE{Agudo:132780,
      author       = {A. Agudo and V. Cayssials and C. Bonet and A. Tjønneland
                      and K. Overvad and M.-C. Boutron-Ruault and A. Affret and G.
                      Fagherazzi and V. Katzke$^*$ and R. Schübel$^*$ and A.
                      Trichopoulou and A. Karakatsani and C. La Vecchia and D.
                      Palli and S. Grioni and R. Tumino and F. Ricceri and S.
                      Panico and B. Bueno-de-Mesquita and P. H. Peeters and E.
                      Weiderpass and G. Skeie and T. H. Nøst and C. Lasheras and
                      M. Rodríguez-Barranco and P. Amiano and M.-D. Chirlaque and
                      E. Ardanaz and B. Ohlsson and J. A. Dias and L. M. Nilsson
                      and R. Myte and K.-T. Khaw and A. Perez-Cornago and M.
                      Gunter and I. Huybrechts and A. J. Cross and K. Tsilidis and
                      E. Riboli and P. Jakszyn},
      title        = {{I}nflammatory potential of the diet and risk of gastric
                      cancer in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition ({EPIC}) study.},
      journal      = {The American journal of clinical nutrition},
      volume       = {107},
      number       = {4},
      issn         = {1938-3207},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2018-00424},
      pages        = {607 - 616},
      year         = {2018},
      abstract     = {Chronic inflammation plays a critical role in the
                      pathogenesis of the 2 major types of gastric cancer. Several
                      foods, nutrients, and nonnutrient food components seem to be
                      involved in the regulation of chronic inflammation.We
                      assessed the association between the inflammatory potential
                      of the diet and the risk of gastric carcinoma, overall and
                      for the 2 major subsites: cardia cancers and noncardia
                      cancers.A total of 476,160 subjects $(30\%$ men, $70\%$
                      women) from the European Investigation into Cancer and
                      Nutrition (EPIC) study were followed for 14 y, during which
                      913 incident cases of gastric carcinoma were identified,
                      including 236 located in the cardia, 341 in the distal part
                      of the stomach (noncardia), and 336 with overlapping or
                      unknown tumor site. The dietary inflammatory potential was
                      assessed by means of an inflammatory score of the diet
                      (ISD), calculated with the use of 28 dietary components and
                      their corresponding inflammatory scores. The association
                      between the ISD and gastric cancer risk was estimated by HRs
                      and $95\%$ CIs calculated by multivariate Cox regression
                      models adjusted for confounders.The inflammatory potential
                      of the diet was associated with an increased risk of gastric
                      cancer. The HR $(95\%$ CI) for each increase in 1 SD of the
                      ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30
                      (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for
                      noncardia cancers. The corresponding values for the highest
                      compared with the lowest quartiles of the ISD were 1.66
                      (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70),
                      respectively.Our results suggest that low-grade chronic
                      inflammation induced by the diet may be associated with
                      gastric cancer risk. This pattern seems to be more
                      consistent for gastric carcinomas located in the cardia than
                      for those located in the distal stomach. This study is
                      listed on the ISRCTN registry as ISRCTN12136108.},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29635497},
      doi          = {10.1093/ajcn/nqy002},
      url          = {https://inrepo02.dkfz.de/record/132780},
}